Advances in Functional Polymer Nanofibers: From Spinning Fabrication Techniques to Recent Biomedical Applications

Author(s)

dos Santos, Danilo M. ^[1] ; Correa, Daniel S. ^[1] ; Medeiros, Eliton S. ^[2] ; Oliveira, Juliano E. ^[3] ; Mattoso, Luiz H. C. ^[1]

Affiliation

^[1] Embrapa Instrumentacao, Nanotechnol Natl Lab Agr LNNA, BR-13560970 Sao Carlos, SP - Brazil

^[2] Fed Univ Paraiba UFPB, Mat & Biosyst Lab LAMAB, Dept Mat Engn DEMAT, BR-58051900 Joao Pessoa, Paraiba - Brazil

^[3] Fed Univ Lavras UFLA, Dept Engn, BR-37200900 Lavras, MG - Brazil

• Document type: Review article
• Source: ACS APPLIED MATERIALS & INTERFACES; v. 12, n. 41, p. 45673-45701, OCT 14 2020.
• Web of Science Citations: 5

Abstract

Functional polymeric micro-/nanofibers have emerged as promising materials for the construction of structures potentially useful in biomedical fields. Among all kinds of technologies to produce polymer fibers, spinning methods have gained considerable attention. Herein, we provide a recent review on advances in the design of micro- and nanofibrous platforms via spinning techniques for biomedical applications. Specifically, we emphasize electrospinning, solution blow spinning, centrifugal spinning, and microfluidic spinning approaches. We first introduce the fundamentals of these spinning methods and then highlight the potential biomedical applications of such micro- and nanostructured fibers for drug delivery, tissue engineering, regenerative medicine, disease modeling, and sensing/biosensing. Finally, we outline the current challenges and future perspectives of spinning techniques for the practical applications of polymer fibers in the biomedical field. (AU)

• FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
• Grantee: Osvaldo Novais de Oliveira Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/12174-4 - Development of hybrid polymer nanofibers for agricultural applications
• Grantee: Daniel Souza Corrêa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/20973-4 - Coaxial electrospun nanofibers based on chitosan for controlled release of antibiotics and periodontic lesion treatment
• Grantee: Danilo Martins dos Santos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral