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Coaxial electrospun nanofibers based on chitosan for controlled release of antibiotics and periodontic lesion treatment

Grant number: 17/20973-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2018
Effective date (End): May 31, 2021
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Daniel Souza Corrêa
Grantee:Danilo Martins dos Santos
Home Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil


Periodontitis is a high-incidence disease among the population and consists of inflammation induced by microorganisms that compromises the periodontal tissues, generating lesions that are difficult to repair. The application of nonwoven fabrics composed by electrospun polymer nanofibers to restore the periodontal structures has been revealed relevant with promising results. In this context, the purpose of this study is the development of nanostructured nonwoven through coaxial electrospinning for controlled antibiotics release with high potential to be applied in periodontal regeneration. The coaxial electrospinning technique will be used to produce fibers with core-shell structure, in which tetracycline derivatives and polyvinyl alcohol will constitute the core of the fibers, whereas the shell will be formed by cross-linked chitosan with phosphate derivatives. Additionally, through the exploration and optimization of the conditions used in the electrospinning, a study will be carried out in order to produce nonwoven with asymmetric structure formed by a denser layer on which porous layers of fiber will be deposited. The obtained materials will be characterized by the morphology, average diameter of the fibers, porosity, hydrophilic/hydrophobic character of the surfaces, water absorption capacity, susceptibility to degradation by lysozyme, crystallinity and with respect to thermal and mechanical properties. In addition, cytotoxicity, antimicrobial activity and drug release kinetics will be evaluated in vitro. This research project will contribute to the advancement in the development of systems for controlled release of drugs potentially applicable in guided tissue regeneration. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FACURE, MURILO HENRIQUE M.; SCHNEIDER, RODRIGO; DOS SANTOS, DANILO M.; CORREA, DANIEL S. Impedimetric electronic tongue based on molybdenum disulfide and graphene oxide for monitoring antibiotics in liquid media. Talanta, v. 217, SEP 2020. Web of Science Citations: 0.
MIGLIORINI, FERNANDA L.; TEODORO, KELCILENE B. R.; DOS SANTOS, DANILO M.; FONSECA, FERNANDO J.; MATTOSO, LUIZ H. C.; CORREA, DANIEL S. Electrospun nanofibers versus drop casting films for designing an electronic tongue: comparison of performance for monitoring geosmin and 2-methylisoborneol in water samples. POLYMERS FOR ADVANCED TECHNOLOGIES, APR 2020. Web of Science Citations: 0.
DOS SANTOS, DANILO M.; CHAGAS, PAULO A. M.; LEITE, ILAIALI S.; INADA, NATALIA M.; DE ANNUNZIO, SARAH R.; FONTANA, CARLA R.; CAMPANA-FILHO, SERGIO P.; CORREA, DANIEL S. Core-sheath nanostructured chitosan-based nonwovens as a potential drug delivery system for periodontitis treatment. International Journal of Biological Macromolecules, v. 142, p. 521-534, JAN 1 2020. Web of Science Citations: 0.
FACCHINATTO, WILLIAM MARCONDES; FIAMINGO, ANDERSON; DOS SANTOS, DANILO MARTINS; CAMPANA-FILHO, SERGIO PAULO. Characterization and physical-chemistry of methoxypoly (ethylene glycol)-g-chitosan. International Journal of Biological Macromolecules, v. 124, p. 828-837, MAR 1 2019. Web of Science Citations: 4.

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