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Coaxial electrospun nanofibers based on chitosan for controlled release of antibiotics and periodontic lesion treatment

Grant number: 17/20973-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2018
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal researcher:Daniel Souza Corrêa
Grantee:Danilo Martins dos Santos
Home Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
Associated research grant:18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis, AP.TEM
Associated scholarship(s):21/11738-7 - Multifunctional 3D-printed stimuli-responsive drug delivery system for periodontitis treatment, BE.EP.PD


Periodontitis is a high-incidence disease among the population and consists of inflammation induced by microorganisms that compromises the periodontal tissues, generating lesions that are difficult to repair. The application of nonwoven fabrics composed by electrospun polymer nanofibers to restore the periodontal structures has been revealed relevant with promising results. In this context, the purpose of this study is the development of nanostructured nonwoven through coaxial electrospinning for controlled antibiotics release with high potential to be applied in periodontal regeneration. The coaxial electrospinning technique will be used to produce fibers with core-shell structure, in which tetracycline derivatives and polyvinyl alcohol will constitute the core of the fibers, whereas the shell will be formed by cross-linked chitosan with phosphate derivatives. Additionally, through the exploration and optimization of the conditions used in the electrospinning, a study will be carried out in order to produce nonwoven with asymmetric structure formed by a denser layer on which porous layers of fiber will be deposited. The obtained materials will be characterized by the morphology, average diameter of the fibers, porosity, hydrophilic/hydrophobic character of the surfaces, water absorption capacity, susceptibility to degradation by lysozyme, crystallinity and with respect to thermal and mechanical properties. In addition, cytotoxicity, antimicrobial activity and drug release kinetics will be evaluated in vitro. This research project will contribute to the advancement in the development of systems for controlled release of drugs potentially applicable in guided tissue regeneration. (AU)

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Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FACCHINATTO, WILLIAM MARCONDES; FIAMINGO, ANDERSON; DOS SANTOS, DANILO MARTINS; CAMPANA-FILHO, SERGIO PAULO. Characterization and physical-chemistry of methoxypoly (ethylene glycol)-g-chitosan. International Journal of Biological Macromolecules, v. 124, p. 828-837, . (17/20973-4, 16/09720-4, 16/20970-2, 10/02526-1)
DOS SANTOS, DANILO M.; CORREA, DANIEL S.; MEDEIROS, ELITON S.; OLIVEIRA, JULIANO E.; MATTOSO, LUIZ H. C.. Advances in Functional Polymer Nanofibers: From Spinning Fabrication Techniques to Recent Biomedical Applications. ACS APPLIED MATERIALS & INTERFACES, v. 12, n. 41, p. 45673-45701, . (17/20973-4, 17/12174-4, 18/22214-6)
DOS SANTOS, DANILO M.; CHAGAS, PAULO A. M.; LEITE, ILAIALI S.; INADA, NATALIA M.; DE ANNUNZIO, SARAH R.; FONTANA, CARLA R.; CAMPANA-FILHO, SERGIO P.; CORREA, DANIEL S.. Core-sheath nanostructured chitosan-based nonwovens as a potential drug delivery system for periodontitis treatment. International Journal of Biological Macromolecules, v. 142, p. 521-534, . (17/20973-4, 18/23015-7, 18/09088-1, 13/07276-1, 17/12174-4)
FACURE, MURILO HENRIQUE M.; SCHNEIDER, RODRIGO; DOS SANTOS, DANILO M.; CORREA, DANIEL S.. Impedimetric electronic tongue based on molybdenum disulfide and graphene oxide for monitoring antibiotics in liquid media. Talanta, v. 217, . (17/20973-4, 17/10582-8, 18/18468-2, 17/12174-4)
FACCHINATTO, WILLIAM MARCONDES; DOS SANTOS, DANILO MARTINS; FIAMINGO, ANDERSON; BERNARDES-FILHO, RUBENS; CAMPANA-FILHO, SERGIO PAULO; DE AZEVEDO, EDUARDO RIBEIRO; COLNAGO, LUIZ ALBERTO. Evaluation of chitosan crystallinity: A high-resolution solid-state NMR spectroscopy approach. Carbohydrate Polymers, v. 250, . (17/24465-3, 16/20970-2, 17/20973-4, 16/09720-4, 19/13656-8)
FACCHINATTO, WILLIAM MARCONDES; GARCIA, RODRIGO HENRIQUE DOS SANTOS; SANTOS, DANILO MARTINS DOS; FIAMINGO, ANDERSON; FLORES, DOUGLAS WILLIAM MENEZES; CAMPANA-FILHO, SERGIO PAULO; AZEVEDO, EDUARDO RIBEIRO DE; COLNAGO, LUIZ ALBERTO. Fast-forward approach of time-domain NMR relaxometry for solid-state chemistry of chitosan. Carbohydrate Polymers, v. 256, . (16/09720-4, 17/20973-4, 19/13656-8)
FACCHINATTO, WILLIAM MARCONDES; DOS SANTOS, DANILO MARTINS; BUKZEM, ANDREA DE LACERDA; MORAES, TIAGO BUENO; HABITZREUTER, FILIPE; DE AZEVEDO, EDUARDO RIBEIRO; COLNAGO, LUIZ ALBERTO; CAMPANA-FILHO, SERGIO PAULO. Insight into morphological, physicochemical and spectroscopic properties of beta-chitin nanocrystalline structures. Carbohydrate Polymers, v. 273, . (19/13656-8, 17/20973-4, 16/20970-2)
BUKZEM, ANDREA DE LACERDA; DOS SANTOS, DANILO MARTINS; LEITE, ILAIALI SOUZA; INADA, NATALIA MAYUMI; CAMPANA-FILHO, SERGIO PAULO. Tuning the properties of carboxymethylchitosan-based porous membranes for potential application as wound dressing. International Journal of Biological Macromolecules, v. 166, p. 459-470, . (10/02526-1, 13/07276-1, 17/20973-4)
SCHNEIDER, RODRIGO; FACURE, MURILO H. M.; CHAGAS, PAULO A. M.; ANDRE, RAFAELA S.; DOS SANTOS, DANILO M.; CORREA, DANIEL S.. Tailoring the Surface Properties of Micro/Nanofibers Using 0D, 1D, 2D, and 3D Nanostructures: A Review on Post-Modification Methods. ADVANCED MATERIALS INTERFACES, v. 8, n. 13, . (18/22214-6, 18/18468-2, 17/10582-8, 16/23793-4, 17/20973-4)
FACCHINATTO, WILLIAM MARCONDES; GALANTE, JOANA; MESQUITA, LETICIA; SILVA, DANIELLA SOUZA; DOS SANTOS, DANILO MARTINS; MORAES, TIAGO BUENO; CAMPANA-FILHO, SERGIO PAULO; COLNAGO, LUIZ ALBERTO; SARMENTO, BRUNO; DAS NEVES, JOSE. Clotrimazole-loaded N -(2-hydroxy)-propyl-3-trimethylammonium, O -palmitoyl chitosan nanoparticles for topical treatment of vulvovaginal candidiasis. Acta Biomaterialia, v. 125, p. 312-321, . (16/20970-2, 19/13656-8, 17/20973-4, 19/11135-0)
MERCANTE, LUIZA A.; PAVINATTO, ADRIANA; PEREIRA, TAMIRES S.; MIGLIORINI, FERNANDA L.; DOS SANTOS, DANILO M.; CORREA, DANIEL S.. Nanofibers interfaces for biosensing: Design and applications. SENSORS AND ACTUATORS REPORTS, v. 3, . (17/20973-4, 18/22214-6, 20/10048-4, 17/21791-7)
SCHNEIDER, RODRIGO; FACURE, MURILO H. M.; ALVARENGA, AUGUSTO D.; CHAGAS, PAULO A. M.; DOS SANTOS, DANILO M.; CORREA, DANIEL S.. Dye Adsorption Capacity of MoS2 Nanoflakes Immobilized on Poly(lactic acid) Fibrous Membranes. ACS APPLIED NANO MATERIALS, v. 4, n. 5, p. 4881-4894, . (17/10582-8, 17/20973-4, 18/22214-6, 18/18468-2, 17/12174-4)
SILVA, DANIELLA SOUZA; FACCHINATTO, WILLIAM MARCONDES; SANTOS, DANILO MARTINS DOS; BONI, FERNANDA ISADORA; VALDES, TALITA ALVARENGA; LEITAO, ANDREI; GREMIAO, MARIA PALMIRA DAFLON; COLNAGO, LUIZ ALBERTO; CAMPANA-FILHO, SERGIO PAULO; RIBEIRO, SIDNEY JOSE LIMA. N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan: Synthesis, physicochemical and biological properties. International Journal of Biological Macromolecules, v. 178, p. 558-568, . (16/20970-2, 19/13656-8, 17/20973-4)
MIGLIORINI, FERNANDA L.; TEODORO, KELCILENE B. R.; DOS SANTOS, DANILO M.; FONSECA, FERNANDO J.; MATTOSO, LUIZ H. C.; CORREA, DANIEL S.. Electrospun nanofibers versus drop casting films for designing an electronic tongue: comparison of performance for monitoring geosmin and 2-methylisoborneol in water samples. POLYMERS FOR ADVANCED TECHNOLOGIES, v. 31, n. 9, . (17/20973-4, 18/09414-6, 14/21184-5, 17/12174-4)
DOS SANTOS, DANILO M.; DE ANNUNZIO, SARAH R.; CARMELLO, JULIANA C.; PAVARINA, ANA C.; FONTANA, CARLA R.; CORREA, DANIEL S.. Combining Coaxial Electrospinning and 3D Printing: Design of Biodegradable Bilayered Membranes with Dual Drug Delivery Capability for Periodontitis Treatment. ACS APPLIED BIO MATERIALS, . (17/20973-4, 18/09088-1, 18/22214-6, 18/23015-7)
CARDOSO, RAFAEL M.; PEREIRA, TAMIRES S.; FACURE, MURILO H. M.; DOS SANTOS, DANILO M.; MERCANTE, LUIZA A.; MATTOSO, LUIZ H. C.; CORREA, DANIEL S.. Current progress in plant pathogen detection enabled by nanomaterials-based (bio)sensors. SENSORS AND ACTUATORS REPORTS, v. 4, . (18/22214-6, 17/10582-8, 17/20973-4)

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