Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fish Oil Diet during Pre-mating, Gestation, and Lactation in Adult Offspring Rats on Cancer Cachexia Prevention

Full text
Oliveira, Sarah Christine Pereira de [1] ; Miyaguti, Natalia Angelo da Silva [1] ; Russell, Steven Thomas [2] ; Tobar, Natalia [3] ; Geraldo, Murilo Vieira [4] ; Gomes-Marcondes, Maria Cristina Cintra [1]
Total Authors: 6
[1] Univ Estadual Campinas, Lab Nutr & Canc, Dept Struct & Funct Biol, Inst Biol, Campinas - Brazil
[2] Aston Univ, Sch Biosci, Coll Hlth & Life Sci, Birmingham, W Midlands - England
[3] Univ Estadual Campinas, Div Nucl Med, Dept Radiol, Sch Med Sci, Campinas - Brazil
[4] Univ Estadual Campinas, Canc Cell Biol Lab, Dept Struct & Funct Biol, Inst Biol, Campinas - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Scope Nutritional supplementation of the maternal diet can modify the cancer susceptibility in adult offspring. Therefore, the authors evaluate the effects of a fish-oil diet administered to a long-term, during pre-mating, gestation, and lactation, in reducing cancer-cachexia damages in adult Walker-256 tumor-bearing offspring. Methods and Results Female rats receive control or fish oil diet during pre-mating, gestation, and lactation. After weaning, male offspring are fed the control diet until adulthood and distributed in (C) control adult-offspring; (W) adult tumor-bearing offspring; (OC) adult-offspring of maternal fish oil diet; (WOC) adult tumor-bearing offspring of maternal fish oil diet groups. Fat body mass is preserved, muscle expression of mechanistic target of rapamicin (mTOR) and eukariotic binding protein of eukariotic factor 4E (4E-BP1) is modified, being associated with lower 20S proteasome protein expression, and the liver alanine aminotransferase (ALT) enzyme content maintained in the WOC group. Also, the OC group shows reduced triglyceridemia. Conclusion In this experimental model of cachexia, the long-term maternal supplementation is a positive strategy to improve liver function and lipid metabolism, as well as to modify muscle proteins expression in the mTOR pathway and also reduce the 20S muscle proteasome protein, without altering the tumor development and muscle wasting in adult tumor-bearing offspring. (AU)

FAPESP's process: 17/10809-2 - Evaluation of DNA methylation profile in muscle and tumour tissue in adult rats, walker 256 tumour bearing, from offspring of rats submitted to COD liver oil diet
Grantee:Sarah Christine Pereira de Oliveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/11932-5 - Molecular Mechanisms of ovarian cancer prevention: investigating the epigenetic consequences of oral contraceptive use
Grantee:Sarah Christine Pereira de Oliveira
Support Opportunities: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 19/13937-7 - Nutrition and Câncer. Molecular, Proteomic and Metabolomic aspects in experimental model of cachexia.
Grantee:Natália Miyaguti Angelo da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/02739-4 - Nutrition and cancer: study of molecular, proteomic and metabolomic aspects of experimental model of cachexia
Grantee:Maria Cristina Cintra Gomes Marcondes
Support Opportunities: Research Projects - Thematic Grants