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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal behavior and the neonatal HPA axis in the Wistar Audiogenic Rat (WAR) strain: Early-life implications for a genetic animal model in epilepsy

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Godoy, Livea Dornela [1] ; Garcia-Cairasco, Norberto [2, 1]
Total Authors: 2
[1] Univ Sao Paulo, Physiol Dept, Ribeirao Preto Sch Med, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Neurosci & Behav Sci, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Epilepsy & Behavior; v. 117, APR 2021.
Web of Science Citations: 0

Epileptogenesis is a multistage process and seizure susceptibility can be influenced by stress early in life. Wistar Audiogenic Rat (WAR) strain is an interesting model to study the association between stress and epilepsy, since it is naturally susceptible to seizures and present changes in the hypothalamus-pitui tary-adrenal (HPA) axis activity. All these features are related to the pathogenic mechanisms usually associated with psychiatric comorbidities present in epilepsy. Therefore, the current study aimed to evaluate the neonate HPA axis function and maternal care under control and stress conditions in the WAR strain. Maternal behavior and neonate HPA axis were evaluated in Wistar and WAR strains under rest and after the presence of stressors. We observed that WAR pups present higher plasmatic corticosterone concentration as compared to Wistar pups. Although WAR dams do not show significant altered maternal behavior at rest, there is a higher latency to recover the litter in the pup retrieval test, while some did not recover all the litter. Wistar Audiogenic Rat dams presented similar behaviors to Wistar dams to a female intruder and maternal care with the pups in the maternal defense test. Taken together, these findings indicate that the WAR strain could show HPA axis disruption early in life and dams present altered maternal behavior under stressful events. Those alterations make the WAR strain an interesting model to evaluate vulnerability to epilepsy and its associated neuropsychiatric comorbidities. (C) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 17/11339-0 - Early life stress and neurodevelopment: Contributions of glucocorticoid plasticity to maturational timing.
Grantee:Lívea Dornela Godoy
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/17959-1 - Characterization of depressive behaviors and morphological aspects involved in early life stress and audiogenic kindling in war strain
Grantee:Lívea Dornela Godoy
Support type: Scholarships in Brazil - Doctorate