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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis

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Author(s):
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Vincentiis, Silvia [1] ; Alcantara, Juliana A. [1] ; Rzezak, Patricia [1] ; Kerr, Daniel S. [2] ; Gattaz, Wagner F. [2] ; van der Linden Jr, Helio ; dos Santos, Bernardo [1] ; Arruda, Francisco [3] ; Chaim-Avancini, Tiffany [4] ; Serpa, Mauricio H. [4] ; Fernandes, Fernando [5] ; Moreno, Ricardo A. [5] ; Busatto, Geraldo F. [4] ; Alessi, Ruda [1] ; Demarque, Renata [1] ; Valente, Kette D. [1]
Total Authors: 16
Affiliation:
[1] Univ Sao Paulo HCFMUSP, Hosp Clin, Inst & Dept Psychiat, Lab Clin Neurophysiol, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo FMUSP, Dept Psychiat, Lab Neurosci LIM 27, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil
[3] van der Linden Jr, Jr., Helio, Goiania Neurol Inst, Praca Gilson Alves de Souza 140, BR-74210250 Goiania, Go - Brazil
[4] Univ Sao Paulo FMUSP, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo HCFMUSP, Hosp Clin, Inst & Dept Psychiat, Mood Disorders Unit GRUDA, Fac Med, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Epilepsy & Behavior; v. 117, APR 2021.
Web of Science Citations: 0
Abstract

Background: Mood disorders are the most frequent psychiatric disorders in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS). The pathophysiological mechanisms in common between TLE and mood disorders include abnormalities in the serotonergic pathway. We aimed to evaluate the association between serotonin transporter genetic polymorphisms - 5-HTTLPR and 5-HTTVNTR - and the presence of mood disorders in patients with TLE-HS. Methods: We evaluated 119 patients with TLE-HS, with and without psychiatric disorder; 146 patients diagnosed with major depressive disorder (MDD), and 113 healthy volunteers. Individuals were geno-typed for the 5-HTTLPR and 5-HTTVNTR polymorphisms. Results: No difference was observed between the TLE-HS groups, healthy controls, and MDD without epilepsy. There was a correlation between the 12-allele of the 5-HTTVNTR and the family history of patients with epilepsy with TLE-HS (p = 0.013). Conclusions: In this study conducted in two Brazilian centers, the serotonin transporter polymorphisms evaluated cannot be associated with depressive disorder in patients with TLE-HS. Still, they do have some influence over some clinical characteristics of epilepsy in TLE-HS. These data may not be reproduced in other populations with distinct ethnic characteristics. (C) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/11361-4 - Association study of polymorphisms in serotoninergic pathway and temporal lobe epilepsy caused by hippocampal sclerosis
Grantee:Kette Dualibi Ramos Valente
Support Opportunities: Regular Research Grants