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Association study of polymorphisms in serotoninergic pathway and temporal lobe epilepsy caused by hippocampal sclerosis

Grant number: 13/11361-4
Support type:Regular Research Grants
Duration: October 01, 2013 - September 30, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Kette Dualibi Ramos Valente
Grantee:Kette Dualibi Ramos Valente
Home Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Assoc. researchers:Daniel Shikanai Kerr ; Ricardo Alberto Moreno ; Wagner Farid Gattaz

Abstract

Depression is the most frequent comorbidity in patients with temporal lobe epilepsy caused by mesial temporal sclerosis (TLE-MTS). The role of serotonin, in epilepsy and depression, has been identified by clinical, neuroimaging and experimental evidences as common denominator for the co-existence of both. Dysfunction of serotoninergic neurotransmission, determined by polymorphisms of genes of the serotoninergic pathway (receptors, monoamine-oxidase A and serotonin transporter), may be related to the co-existence of these conditions, as a marker for the presence of depression in this specific group of patients. The main endpoint of the current study is to determine the presence of polymorphisms related to the serotoninergic neurotransmission and the presence of psychiatric disorders in patients with TLE-MTS compared to a group of patients with major depressive disorder without epilepsy and with healthy volunteers. Our secondary endpoint is to evaluate the influence of theses polymorphisms in the clinical characteristics of the epilepsy in patients with TLE-MTS. For this purpose, we will evaluate 100 patients with TLE-MTS and with the diagnosis of depression classified according to DSM-IV-TR, using clinical interview and SCID-I/P (Structured Clinical Interview for DSM-IV Axis I Disorders) 100 patients with major depression according to DSM-IV-TR, without psychosis and 100 healthy controls. The genotyping will be performed to screen polymorphisms of genes related to serotoninergic neurotransmission - genes encoding the serotonin transporter, serotonin receptors and monoamine oxidase A. (AU)

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VINCENTIIS, SILVIA; ALCANTARA, JULIANA; RZEZAK, PATRICIA; KERR, DANIEL; DOS SANTOS, BERNARDO; ALESSI, RUDA; VAN DER LINDEN, HELIO; ARRUDA, FRANCISCO; CHAIM-AVANCINI, TIFFANY; SERPA, MAURICIO; BUSATTO, GERALDO; GATTAZ, WAGNER; DEMARQUE, RENATA; VALENTE, KETTE D. Higher transcription alleles of the MAOA-uVNTR polymorphism are associated with higher seizure frequency in temporal lobe epilepsy. Epilepsy Research, v. 149, p. 26-29, JAN 2019. Web of Science Citations: 0.
RZEZAK, PATRICIA; MOSCHETTA, SYLVIE PAES; MENDONCA, MELANIE; MAIA NOBRE PAIVA, MARIA LUISA; COAN, ANA CAROLINA; GUERREIRO, CARLOS; RAMOS VALENTE, KETTE DUALIBI. Higher IQ in juvenile myoclonic epilepsy: Dodging cognitive obstacles and ``masking{''} impairments. Epilepsy & Behavior, v. 86, p. 124-130, SEP 2018. Web of Science Citations: 1.
VINCENTIIS, SILVIA; ALCANTARA, JULIANA; RZEZAK, PATRICIA; KERR, DANIEL S.; GATTAZ, WAGNER F.; VAN DER LINDEN, JR., HELIO; DOS SANTOS, BERNARDO; MELO-SOUZA, SEBASTIAO E.; ARRUDA, FRANCISCO; RAGAZZO, PAULO; CHAIM-AVANCINI, TIFFANY; SERPA, MAURICIO H.; FERNANDES, FERNANDO; MORENO, RICARDO A.; BUSATTO, GERALDO; ALESSI, RUDA; DEMARQUE, RENATA; VALENTE, KETTE D. Genetic polymorphisms of the 5HT receptors are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis. Epilepsy & Behavior, v. 83, p. 181-185, JUN 2018. Web of Science Citations: 1.
LIMA, ELLEN M.; RZEZAK, PATRICIA; GUIMARAES, CATARINA A.; MONTENEGRO, MARIA A.; GUERREIRO, MARILISA M.; VALENTE, KETTE D. The executive profile of children with Benign Epilepsy of Childhood with Centrotemporal Spikes and Temporal Lobe Epilepsy. Epilepsy & Behavior, v. 72, p. 173-177, JUL 2017. Web of Science Citations: 4.
RZEZAK, PATRICIA; GUIMARAES, CATARINA A.; GUERREIRO, MARILISA M.; VALENTE, KETTE D. The impact of intelligence on memory and executive functions of children with temporal lobe epilepsy: Methodological concerns with clinical relevance. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, v. 21, n. 3, p. 500-506, MAY 2017. Web of Science Citations: 4.
RZEZAK, PATRICIA; LIMA, ELLEN MARISE; GARGARO, ANA CAROLINA; COIMBRA, ERICA; DE VINCENTIIS, SILVIA; VELASCO, TONICARLO RODRIGUES; LEITE, JOAO PEREIRA; BUSATTO, GERALDO F.; VALENTE, KETTE D. Everyday memory impairment in patients with temporal lobe epilepsy caused by hippocampal sclerosis. Epilepsy & Behavior, v. 69, p. 31-36, APR 2017. Web of Science Citations: 8.
VALENTE, KETTE D.; DE PAOLA, LUCIANO; PALMINI, ANDRE; FAVERET, EDUARDO; DE ARAUJO-FILHO, GERARDO MARIA; VAN DER LINDEN, HELIO; BIANCHIN, MARINO M.; WALZ, ROGER; ALESSI, RUDA; VELASCO, TONICARLO; TEIXEIRA, WAGNER A.; LAFRANCE, JR., W. CURT. The approach to patients with psychogenic nonepileptic seizures in epilepsy surgery centers regarding diagnosis, treatment, and education. Epilepsy & Behavior, v. 68, p. 78-83, MAR 2017. Web of Science Citations: 6.
RZEZAK, PATRICIA; LIMA, ELLEN MARISE; PEREIRA, FABRICIO; GARGARO, ANA CAROLINA; COIMBRA, ERICA; DE VINCENTIIS, SILVIA; VELASCO, TONICARLO RODRIGUES; LEITE, JOAO PEREIRA; BUSATTO, GERALDO F.; VALENTE, KETTE D. Decision-making in patients with temporal lobe epilepsy: Delay gratification ability is not impaired in patients with hippocampal sclerosis. Epilepsy & Behavior, v. 60, p. 158-164, JUL 2016. Web of Science Citations: 4.
RZEZAK, PATRICIA; MOSCHETTA, SYLVIE P.; LIMA, ELLEN; CASTRO, CAROLINA X. L.; VINCENTIIS, SILVIA; COAN, ANA CAROLINA; GUERREIRO, CARLOS; BUSATTO FILHO, GERALDO; VALENTE, KETTE D. Distinct domains of impulsivity are impaired in juvenile myoclonic epilepsy but not in temporal lobe epilepsy. Epilepsy & Behavior, v. 45, p. 44-48, APR 2015. Web of Science Citations: 3.
VALENTE, KETTE D.; RZEZAK, PATRICIA; LAFRANCE, JR., W. CURT. Standard medical care for psychogenic nonepileptic seizures in Brazil. Epilepsy & Behavior, v. 45, p. 128-135, APR 2015. Web of Science Citations: 6.
DA FONSECA, NATASCHA C.; JOAQUIM, HELENA P. G.; TALIB, LEDA L.; DE VINCENTIIS, SILVIA; GATTAZ, WAGNER F.; VALENTE, KETTE D. Hippocampal serotonin depletion is related to the presence of generalized tonic-clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy. Epilepsy Research, v. 111, p. 18-25, MAR 2015. Web of Science Citations: 9.
RZEZAK, PATRICIA; VALENTE, KETTE D.; DUCHOWNY, MICHAEL S. Temporal lobe epilepsy in children: Executive and mnestic impairments. Epilepsy & Behavior, v. 31, p. 117-122, FEB 2014. Web of Science Citations: 16.

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