| Grant number: | 13/11361-4 |
| Support Opportunities: | Regular Research Grants |
| Start date: | October 01, 2013 |
| End date: | September 30, 2015 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Kette Dualibi Ramos Valente |
| Grantee: | Kette Dualibi Ramos Valente |
| Host Institution: | Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Associated researchers: | Daniel Shikanai Kerr ; Ricardo Alberto Moreno ; Wagner Farid Gattaz |
Abstract
Depression is the most frequent comorbidity in patients with temporal lobe epilepsy caused by mesial temporal sclerosis (TLE-MTS). The role of serotonin, in epilepsy and depression, has been identified by clinical, neuroimaging and experimental evidences as common denominator for the co-existence of both. Dysfunction of serotoninergic neurotransmission, determined by polymorphisms of genes of the serotoninergic pathway (receptors, monoamine-oxidase A and serotonin transporter), may be related to the co-existence of these conditions, as a marker for the presence of depression in this specific group of patients. The main endpoint of the current study is to determine the presence of polymorphisms related to the serotoninergic neurotransmission and the presence of psychiatric disorders in patients with TLE-MTS compared to a group of patients with major depressive disorder without epilepsy and with healthy volunteers. Our secondary endpoint is to evaluate the influence of theses polymorphisms in the clinical characteristics of the epilepsy in patients with TLE-MTS. For this purpose, we will evaluate 100 patients with TLE-MTS and with the diagnosis of depression classified according to DSM-IV-TR, using clinical interview and SCID-I/P (Structured Clinical Interview for DSM-IV Axis I Disorders) 100 patients with major depression according to DSM-IV-TR, without psychosis and 100 healthy controls. The genotyping will be performed to screen polymorphisms of genes related to serotoninergic neurotransmission - genes encoding the serotonin transporter, serotonin receptors and monoamine oxidase A. (AU)
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