| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Univ Estadual Campinas, Lab Immunometab, Dept Genet Evolut Microbiol & Immunol, Inst Biol, Campinas, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, SP - Brazil
[3] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | CURRENT OPINION IN PHARMACOLOGY; v. 58, p. 44-51, JUN 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Adipose tissue (AT) performs immunoregulatory functions beyond fat storage. In addition to adipocytes, AT has a diverse spectrum of resident and infiltrating immune cells in health and disease. Immune cells contribute to the homeostatic function of AT by adapting their metabolism in accordance with the microenvironment. However, how the metabolic reprogramming of immune cells affects their inflammatory profile and the subsequent implication for adipocyte function is not completely elucidated. Here, we discuss the available data on metabolic regulatory processes implicated in the control of adipose tissue-resident immune cells and their crosstalk with adipocytes. (AU) | |
| FAPESP's process: | 19/19435-3 - The role of DNA damage and mitochondrial function in vascular, immune and neurological ageing (DNA MoVINg) |
| Grantee: | Carlos Frederico Martins Menck |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/25973-8 - Mitoimmunity: mitochondria adaptation in pathological and physiological states |
| Grantee: | Pedro Manoel Mendes de Moraes Vieira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/15626-8 - Macrophages and T lymphocytes immunometabolism in metabolic and inflammatory diseases |
| Grantee: | Pedro Manoel Mendes de Moraes Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/18031-8 - HIF-1 alpha in metabolic and functional control of adipose tissue resident macrophages in diabetes induced by obesity |
| Grantee: | Gustavo Gastão Davanzo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |