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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Quorum Sensing Auto-Inducer 2 (AI-2) Stimulates Nitrogen Fixation and Favors Ethanol Production over Biomass Accumulation in Zymomonas mobilis

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Author(s):
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Alencar, Valquiria Campos [1, 2] ; Silva, Juliana de Fatima dos Santos [1] ; Vilas Boas, Renata Ozelami [2] ; Farnezio, Vinicius Manganaro [1] ; de Maria, Yara N. L. F. [2] ; Aciole Barbosa, David [2] ; Almeida, Alex Tramontin [3] ; de Souza, Emanuel Maltempi [3] ; Muller-Santos, Marcelo [3] ; Jabes, Daniela L. [2] ; Menegidio, Fabiano B. [2] ; Costa de Oliveira, Regina [2] ; Rodrigues, Tiago [1] ; Tersariol, Ivarne Luis dos Santos [4] ; Walmsley, Adrian R. [5] ; Nunes, Luiz R. [1]
Total Authors: 16
Affiliation:
[1] Univ Fed ABC UFABC, Ctr Ciencias Nat & Humanas, Alameda Univ S-N, BR-09606045 Sao Bernardo Do Campo, SP - Brazil
[2] Univ Mogi Cruzes UMC, Nucleo Integrado Biotecnol, Av Dr Candido Xavier Almeida Souza 200, BR-08780911 Mogi Das Cruzes, SP - Brazil
[3] Univ Fed Parana UFPR, Setor Ciencias Biol, Dept Bioquim & Biol Mol, Rua Cel Francisco H Santos 100, BR-81531980 Curitiba, Parana - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Dept Bioquim, Rua Tres Maio 100, BR-04044020 Sao Paulo, SP - Brazil
[5] Univ Durham, Dept Biosci, South Rd, Durham DH1 3LE - England
Total Affiliations: 5
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 11 JUN 2021.
Web of Science Citations: 1
Abstract

Autoinducer 2 (or AI-2) is one of the molecules used by bacteria to trigger the Quorum Sensing (QS) response, which activates expression of genes involved in a series of alternative mechanisms, when cells reach high population densities (including bioluminescence, motility, biofilm formation, stress resistance, and production of public goods, or pathogenicity factors, among others). Contrary to most autoinducers, AI-2 can induce QS responses in both Gram-negative and Gram-positive bacteria, and has been suggested to constitute a trans-specific system of bacterial communication, capable of affecting even bacteria that cannot produce this autoinducer. In this work, we demonstrate that the ethanologenic Gram-negative bacterium Zymomonas mobilis (a non-AI-2 producer) responds to exogenous AI-2 by modulating expression of genes involved in mechanisms typically associated with QS in other bacteria, such as motility, DNA repair, and nitrogen fixation. Interestingly, the metabolism of AI-2-induced Z. mobilis cells seems to favor ethanol production over biomass accumulation, probably as an adaptation to the high-energy demand of N-2 fixation. This opens the possibility of employing AI-2 during the industrial production of second-generation ethanol, as a way to boost N-2 fixation by these bacteria, which could reduce costs associated with the use of nitrogen-based fertilizers, without compromising ethanol production in industrial plants. (AU)

FAPESP's process: 17/13197-8 - Characterization of promoter elements responsive to the quorum sensing (QS) auto-inducer 2 (AI-2) in Zymomonas mobilis
Grantee:Luiz Roberto Nunes
Support type: Program for Research on Bioenergy (BIOEN) - Regular Program Grants
FAPESP's process: 17/08112-3 - Composition and influence of the intestinal microbiome in mice, during the process of cachexia development, induced by transplantation of Lewis lung carcinoma (LLC) cells
Grantee:Daniela Leite Jabes
Support type: Regular Research Grants