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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparison of Resveratrol Supplementation and Energy Restriction Effects on Sympathetic Nervous System Activity and Vascular Reactivity: A Randomized Clinical Trial

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Author(s):
Goncalinho, Gustavo Henrique Ferreira [1] ; Roggerio, Alessandra [1] ; Goes, Marisa Fernandes da Silva [1] ; Avakian, Solange Desiree [1] ; Leal, Dalila Pinheiro [1] ; Strunz, Celia Maria Cassaro [1] ; Mansur, Antonio de Padua [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Heart, Sch Med, Chron Coronariopathies Clin Unit, BR-05403000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Molecules; v. 26, n. 11 JUN 2021.
Web of Science Citations: 0
Abstract

Background: Chronic sympathetic nervous system activation is associated with endothelial dysfunction and cardiometabolic disease, which may be modulated by resveratrol (RSV) and energy restriction (ER). This study aimed to examine the effects of RSV and ER on plasma noradrenaline (NA), flow-mediated vasodilation (ed-FMD), and endothelium-independent nitrate-mediated vasodilation (ei-NMD). Methods: The study included 48 healthy adults randomized to 30-days intervention of RSV or ER. Results: Waist circumference, total cholesterol, HDL-c, LDL-c, apoA-I, and plasma NA decreased in the ER group, whilst RSV increased apoB and total cholesterol, without changing plasma NA. No effects on vascular reactivity were observed in both groups. Plasma NA change was positively correlated with total cholesterol (r = 0.443; p = 0.002), triglycerides (r = 0.438; p = 0.002), apoA-I (r = 0.467; p = 0.001), apoB (r = 0.318; p = 0.032) changes, and ei-NMD (OR = 1.294; 95%CI: 1.021-1.640). Conclusions: RSV does not improve cardiometabolic risk factors, sympathetic activity, and endothelial function. ER decreases plasma NA and waist circumference as well as improves blood lipids, but does not modify endothelial function. Finally, plasma NA was associated with ei-NMD, which could be attributed to a higher response to nitrate in patients with greater resting sympathetic vasoconstriction. (AU)

FAPESP's process: 12/01051-5 - Influence of caloric restriction and resveratrol in the sirtuin system in women and men aged 55 to 65 years
Grantee:Antonio de Padua Mansur
Support type: Regular Research Grants