Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

Author(s):Show less -

Iatecola, Amilton ^[1] ; Longhitano, Guilherme Arthur ^{[2, 3, 4]} ; Martinez Antunes, Luiz Henrique ^{[5, 4]} ; Jardini, Andre Luiz ^{[3, 4]} ; Miguel, Emilio de Castro ^[6] ; Beres, Miloslav ^{[4, 6]} ; Lambert, Carlos Salles ^[7] ; Andrade, Tiago Neves ^[1] ; Buchaim, Rogerio Leone ^[8] ; Buchaim, Daniela Vieira ^{[9, 10]} ; Pomini, Karina Torres ^{[8, 9]} ; Dias, Jefferson Aparecido ^{[9, 11]} ; Mesquita Serva Spressao, Daniele Raineri ^[9] ; Felix, Marcilio ^[12] ; Camargo Cardoso, Guinea Brasil ^[5] ; da Cunha, Marcelo Rodrigues ^[1]

Affiliation:Show less -

^[1] Fac Med Jundiai, BR-13202550 Jundiai, SP - Brazil

^[2] Ctr Informat Technol Renato Archer CTI, BR-13069901 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Sch Chem Engn, UNICAMP, BR-13083852 Campinas, SP - Brazil

^[4] Natl Inst Biofabricat INCT BIOFABRIS, BR-13083852 Campinas, SP - Brazil

^[5] Univ Estadual Campinas, Sch Mech Engn, UNICAMP, BR-13083860 Campinas, SP - Brazil

^[6] Univ Fed Ceara, Dept Met & Mat Engn, BR-60440554 Fortaleza, Ceara - Brazil

^[7] Univ Estadual Campinas, Gleb Wataghin Inst Phys, UNICAMP, BR-13083859 Campinas, SP - Brazil

^[8] Univ Sao Paulo, Bauru Sch Dent FOB USP, Dept Biol Sci, BR-17012901 Bauru, SP - Brazil

^[9] Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Marilia, SP - Brazil

^[10] Univ Ctr Adamantina UniFAI, Med Sch, BR-17800000 Adamantina, SP - Brazil

^[11] Univ Marilia UNIMAR, Postgrad Program Law, BR-17525902 Marilia, SP - Brazil

^[12] Univ Marilia UNIMAR, Vet Med Sch, BR-17525902 Marilia, SP - Brazil

• Document type: Journal article
• Source: PHARMACEUTICS; v. 13, n. 5 MAY 2021.
• Web of Science Citations: 0

Abstract

Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant. (AU)

• FAPESP's process: 20/05612-8 - Development of customized mandible prosthesis produced by additive manufacturing and functionalized for local drug delivery
• Grantee: Guilherme Arthur Longhitano
• Support Opportunities: Scholarships in Brazil - Post-Doctoral