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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Larvicidal Activity of Essential Oils From Piper Species Against Strains of Aedes aegypti (Diptera: Culicidae) Resistant to Pyrethroids

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Author(s):
Pereira Filho, Adalberto Alves [1] ; Pessoa, Grasielle C. D'Avila [1] ; Yamaguchi, Lydia F. [2] ; Stanton, Mariana Alves [2] ; Serravite, Artur M. [1] ; Pereira, Rafael H. M. [1] ; Neves, Welber S. [2] ; Kato, Massuo Jorge [2]
Total Authors: 8
Affiliation:
[1] Univ Fed Minas Gerais, Dept Parasitol ICB, Lab Fisiol Insetos Hematofagos, Belo Horizonte, MG - Brazil
[2] Univ Sao Paulo, Dept Fundamental Chem, Lab Nat Prod Chem, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FRONTIERS IN PLANT SCIENCE; v. 12, JUN 4 2021.
Web of Science Citations: 0
Abstract

The continuous and indiscriminate use of insecticides has been responsible for the emergence of insecticide resistant vector insect populations, especially in Aedes aegypti. Thus, it is urgent to find natural insecticide compounds with novel mode of action for vector control. The goal of this study was to investigate the larvicidal activity of essential oils (EOs) from Piper species against A. aegypti characterized as resistant and susceptible strains to pyrethroids. The EOs from leaves of 10 Piper species were submitted to the evaluation of larvicidal activity in populations of A. aegypti in agreement with the (World Health Organization, 2005) guidelines. The resistance of the strains characterized by determining the lethal concentrations (LCs) with the insecticide deltamethrin (positive control). The major compounds of the EOs from Piper species was identified by GC-MS. The EOs from Piper aduncum, P. marginatum, P. gaudichaudianum, P. crassinervium, and P. arboreum showed activity of up to 90% lethality at 100 ppm (concentration for screening). The activities of the EOs from these 6 species showed similar LCs in both susceptible strain (Rockefeller) and resistant strains (Pampulha and Venda Nova) to pyrethroids. The major compounds identified in the most active EO were available commercially and included beta-Asarone, (E)-Anethole, (E)-beta-Caryophyllene, gamma-Terpinene, p-Cymene, Limonene, alpha-Pinene, and beta-Pinene. Dillapiole was purified by from EO of P. aduncum. The phenylpropanoids {[}Dillapiole, (E)-Anethole and beta-Asarone] and monoterpenes (gamma-Terpinene, p-Cymene, Limonene, alpha-Pinene, and beta-Pinene) showed larvicidal activity with mortality between 90 and 100% and could account for the toxicity of these EOs, but the sesquiterpene (E)-beta-Caryophyllene, an abundant component in the EOs of P. hemmendorffii and P. crassinervium, did not show activity on the three populations of A. aegypti larvae at a concentration of 100 ppm. These results indicate that Piper's EOs should be further evaluated as a potential larvicide, against strains resistant to currently used pesticides, and the identification of phenylpropanoids and monoterpenes as the active compounds open the possibility to study their mechanism of action. (AU)

FAPESP's process: 14/50316-7 - Dimensions US-Biota São Paulo: Chemically mediated multi-trophic interaction diversity across tropical gradients
Grantee:Massuo Jorge Kato
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants