Central odontogenic fibroma: an international multicentric study of 62 cases

Author(s):Show less -

Roza, Ana Luiza Oliveira Correa ^[1] ; Sousa, Emanuel Mendes ^[2] ; Leite, Amanda Almeida ^[1] ; Amaral-Silva, Gleyson Kleber ^[1] ; Morais, Thayna Melo de Lima ^[1] ; Wagner, Vivian Petersen ^[1] ; Schuch, Lauren Frenzel ^[1] ; Vasconcelos, Ana Carolina Uchoa ^[3] ; de Arruda, Jose Alcides Almeida ^[4] ; Mesquita, Ricardo Alves ^[4] ; Fonseca, Felipe Paiva ^{[1, 4, 5]} ; Abrahao, Aline Correa ^[2] ; Agostini, Michelle ^[2] ; Andrade, de Bruno Augusto Benevenuto ^[2] ; da Silveira, Ericka Janine Dantas ^[6] ; Martinez-Flores, Rene ^[7] ; Rondanelli, Benjamin Martinez ^[8] ; Alberdi-Navarro, Javier ^[9] ; Robinson, Liam ^[5] ; Marin, Constanza ^[10] ; Assuncao Junior, Jose Narciso Rosa ^[11] ; Valiati, Renato ^[12] ; Fregnani, Eduardo Rodrigues ^[13] ; Santos-Silva, Alan Roger ; Lopes, Marcio Ajudarte ^[1] ; Hunter, Keith D. ^{[5, 10]} ; Khurram, Syed Ali ^[10] ; Speight, Paul M. ^[10] ; Mosqueda-Taylor, Adalberto ^[14] ; van Heerden, Willie F. P. ^[5] ; Carlos, Roman ^[15] ; Wright, John M. ^[16] ; de Almeida, Oslei Paes ^[1] ; Romanach, Mario Jose ^[2] ; Vargas, Pablo Agustin ^{[1, 5]}

Affiliation:Show less -

^[1] Univ Campinas UNICAMP, Dept Oral Diag, Piracicaba Dent Sch, Sao Paulo - Brazil

^[2] Fed Univ Rio de Janeiro UFRJ, Sch Dent, Dept Oral Diag & Pathol, Rio De Janeiro - Brazil

^[3] Fed Univ Pelotas UFPel, Sch Dent, Diagnost Ctr Oral Dis, Pelotas, RS - Brazil

^[4] Fed Univ Minas Gerais UFMG, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil

^[5] Univ Pretoria, Dept Oral Pathol & Oral Biol, Sch Dent, Fac Hlth Sci, Pretoria - South Africa

^[6] Fed Univ Rio Grande Norte UFRN, Dept Dent, Postgrad Program Dent Sci, Natal, RN - Brazil

^[7] Andres Bello Univ, Dept Oral Pathol & Oral Med, Fac Dent, Vina Del Mar - Chile

^[8] Mayor Univ, Dept Oral Pathol & Oral Med, Fac Dent, Santiago - Chile

^[9] Univ Basque Country UPV EHU, Oral Med & Oral & Maxillofacial Pathol Unit, Dent Clin Serv, Dept Stomatol 2, Leioa - Spain

^[10] Univ Sheffield, Acad Unit Oral & Maxillofacial Med & Pathol, Sch Clin Dent, Sheffield, S Yorkshire - England

^[11] Metropolitan Univ Santos UNIMES, Sch Dent, Santos, SP - Brazil

^[12] Planalto Catarinense Univ UNIPLAC, Sch Dent, Lages, SC - Brazil

^[13] Hosp Sirio Libanes, Ctr Oncol Mol, Sao Paulo - Brazil

^[14] Univ Autonoma Metropolitana Xochimilco, Dept Atenc Salud, Mexico City, DF - Mexico

^[15] Hosp Herrera Llerandi, Pathol Sect, Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala

^[16] Texas A&M Univ, Dept Diagnost Sci, Coll Dent, College Stn, TX - USA

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 131, n. 5, p. 549-557, MAY 2021.
• Web of Science Citations: 0

Abstract

Objective. The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). Study Design. Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. Results. There were 43 females and 19 males (average age 33.9 years; range 8-63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. Conclusions. To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells. (AU)

• FAPESP's process: 19/02539-0 - Multicentric clinicopathological and proteomic study of adenomatoid odontogenic tumors
• Grantee: Ana Luiza Oliveira Corrêa Roza
• Support Opportunities: Scholarships in Brazil - Master