Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Uremic Toxins: An Alarming Danger Concerning the Cardiovascular System

Full text
Author(s):
Falconi, Carlos Alexandre [1] ; Junho, Carolina Victoria da Cruz [1] ; Fogaca-Ruiz, Fernanda [1] ; Vernier, Imara Caridad Stable [1] ; da Cunha, Regiane Stafim [2] ; Stinghen, Andrea Emilia Marques [2] ; Carneiro-Ramos, Marcela Sorelli [1]
Total Authors: 7
Affiliation:
[1] Fed Univ ABC, Ctr Nat & Human Sci CCNH, Lab Cardiovasc Immunol, Santo Andre, SP - Brazil
[2] Univ Fed Parana, Basic Pathol Dept, Expt Nephrol Lab, Curitiba, Parana - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, MAY 14 2021.
Web of Science Citations: 0
Abstract

The kidneys and heart share functions with the common goal of maintaining homeostasis. When kidney injury occurs, many compounds, the so-called ``uremic retention solutes{''} or ``uremic toxins,{''} accumulate in the circulation targeting other tissues. The accumulation of uremic toxins such as p-cresyl sulfate, indoxyl sulfate and inorganic phosphate leads to a loss of a substantial number of body functions. Although the concept of uremic toxins is dated to the 1960s, the molecular mechanisms capable of leading to renal and cardiovascular injuries are not yet known. Besides, the greatest toxic effects appear to be induced by compounds that are difficult to remove by dialysis. Considering the close relationship between renal and cardiovascular functions, an understanding of the mechanisms involved in the production, clearance and overall impact of uremic toxins is extremely relevant for the understanding of pathologies of the cardiovascular system. Thus, the present study has as main focus to present an extensive review on the impact of uremic toxins in the cardiovascular system, bringing the state of the art on the subject as well as clinical implications related to patient's therapy affected by chronic kidney disease, which represents high mortality of patients with cardiac comorbidities. (AU)

FAPESP's process: 19/11077-0 - Cardiac alterations induced by renal inflammation models: participation of the Klotho/FGF-23 axis
Grantee:Marcela Sorelli Carneiro Ramos
Support Opportunities: Regular Research Grants
FAPESP's process: 15/19107-5 - TLR4 and complement system : possible key mechanism in renal ischemia/reperfusion induced cardiac hypertrophy
Grantee:Marcela Sorelli Carneiro Ramos
Support Opportunities: Regular Research Grants
FAPESP's process: 18/03089-6 - Role of the Klotho/FGF23 axis in the development of Type 3 Cardiorenal Syndrome induced by ischemic renal injury
Grantee:Carolina Victória da Cruz Junho
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)