| Full text | |
| Author(s): |
Neres, Nayara B. R.
[1]
;
Montagnini, Daniel
[1]
;
Ferreira, Daniele S.
[1]
;
Parreira, Renato L. T.
[1]
;
Orenha, Renato P.
[1]
;
Lima, Thais C.
[1]
;
Molina, Eduardo F.
[1]
;
Cunha, Wilson R.
[1]
;
Silva, Marcio L. A.
[1]
;
Esperandim, Viviane R.
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | CHEMISTRY & BIODIVERSITY; v. 18, n. 6 JUN 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
In this study, the trypomastigotes of a Y strain of Trypanosoma cruzi were inoculated intraperitoneally into male BALB/c mice weighing approximately 25 g each, which were divided into groups for evaluation of the trypanocidal activity. For the treatment of experimental groups, encapsulated and unencapsulated (-)-cubebin, Benznidazole, and two groups as negative controls were used. The encapsulated (-)-cubebin showed a 68.1 % encapsulation efficiency. The parasitemia peak of substances remained around the 9(th) day after the observed reduction in the number of circulating trypomastigotes. The encapsulated (-)-cubebin and (-)-cubebin unloaded showed a decrease of 61.3 % and 58.5 % in the number of parasites as compared to the negative control, respectively. Moreover, animals treated with encapsulated (-)-cubebin had a higher survival time as compared to the other groups. In conclusion, the results obtained were more promising for encapsulated (-)-cubebin as compared to unloaded particles. (AU) | |
| FAPESP's process: | 17/24856-2 - The Mechanism of the Substitution Reaction of the Ligand Nitrosyl by Aqua in Ruthenium Coordination Compounds |
| Grantee: | Renato Pereira Orenha |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/04880-5 - Trypanocidal activity evaluation of encapsulated lignan (-)- cubebin in system in vivo in the acute phase of experimental infection |
| Grantee: | Nayara Bruna dos Reis Neres |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 10/17378-8 - Study of the immunomodulatory activity of lignans and neolignans obtained by partial synthesis and oxidative coupling as a potential in developing new antiparasitic drugs |
| Grantee: | Márcio Luís Andrade e Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/05049-2 - Development of polymeric nanaparticles and biodegradable systems containing lignans and evaluation its Chagas disease and schistosomiasis activities in vitro and in vivo |
| Grantee: | Márcio Luís Andrade e Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/05952-4 - Preparation and characterization of polymeric nanoparticles containing (-)-6,6'-dinitrohinokinin and (±)-licarina-A as potential drugs in the assessment of the schistosomicidal activity |
| Grantee: | Thaís Coelho Lima |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/07623-8 - The use of quantum-mechanical methods to study the bonds and chemical interactions in self-organizing systems with applications in catalysis, medicinal chemistry, electrochromism, energy storage and conversion |
| Grantee: | Renato Luis Tame Parreira |
| Support Opportunities: | Research Grants - Young Investigators Grants |