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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In Vivo and in Silico Trypanocidal Activity Evaluation of (-)-Cubebin Encapsulated in PLGA Microspheres as Potential Treatment in Acute Phase

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Neres, Nayara B. R. [1] ; Montagnini, Daniel [1] ; Ferreira, Daniele S. [1] ; Parreira, Renato L. T. [1] ; Orenha, Renato P. [1] ; Lima, Thais C. [1] ; Molina, Eduardo F. [1] ; Cunha, Wilson R. [1] ; Silva, Marcio L. A. [1] ; Esperandim, Viviane R. [1]
Total Authors: 10
[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CHEMISTRY & BIODIVERSITY; v. 18, n. 6 JUN 2021.
Web of Science Citations: 0

In this study, the trypomastigotes of a Y strain of Trypanosoma cruzi were inoculated intraperitoneally into male BALB/c mice weighing approximately 25 g each, which were divided into groups for evaluation of the trypanocidal activity. For the treatment of experimental groups, encapsulated and unencapsulated (-)-cubebin, Benznidazole, and two groups as negative controls were used. The encapsulated (-)-cubebin showed a 68.1 % encapsulation efficiency. The parasitemia peak of substances remained around the 9(th) day after the observed reduction in the number of circulating trypomastigotes. The encapsulated (-)-cubebin and (-)-cubebin unloaded showed a decrease of 61.3 % and 58.5 % in the number of parasites as compared to the negative control, respectively. Moreover, animals treated with encapsulated (-)-cubebin had a higher survival time as compared to the other groups. In conclusion, the results obtained were more promising for encapsulated (-)-cubebin as compared to unloaded particles. (AU)

FAPESP's process: 09/05049-2 - Development of polymeric nanaparticles and biodegradable systems containing lignans and evaluation its Chagas disease and schistosomiasis activities in vitro and in vivo
Grantee:Márcio Luís Andrade e Silva
Support type: Regular Research Grants
FAPESP's process: 13/04880-5 - Trypanocidal activity evaluation of encapsulated lignan (-)- cubebin in system in vivo in the acute phase of experimental infection
Grantee:Nayara Bruna dos Reis Neres
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/24856-2 - The Mechanism of the Substitution Reaction of the Ligand Nitrosyl by Aqua in Ruthenium Coordination Compounds
Grantee:Renato Pereira Orenha
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/07623-8 - The use of quantum-mechanical methods to study the bonds and chemical interactions in self-organizing systems with applications in catalysis, medicinal chemistry, electrochromism, energy storage and conversion
Grantee:Renato Luis Tame Parreira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 11/05952-4 - Preparation and characterization of polymeric nanoparticles containing (-)-6,6'-dinitrohinokinin and (±)-licarina-A as potential drugs in the assessment of the schistosomicidal activity
Grantee:Thaís Coelho Lima
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 10/17378-8 - Study of the immunomodulatory activity of lignans and neolignans obtained by partial synthesis and oxidative coupling as a potential in developing new antiparasitic drugs
Grantee:Márcio Luís Andrade e Silva
Support type: Regular Research Grants