Do Lifestyle Interventions in Pregnant Women with Overweight or Obesity Have an Effect on Neonatal Adiposity? A Systematic Review with Meta-Analysis

Author(s)

Baroni, Naiara F. ^[1] ; Baldoni, Nayara R. ^{[2, 3]} ; Alves, Geisa C. S. ^{[2, 4]} ; Crivellenti, Livia C. ^[1] ; Braga, Giordana C. ^[1] ; Sartorelli, Daniela S. ^[5]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Grad Program Publ Hlth, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Sao Joao del Rei, Grad Program Hlth Sci, BR-36307352 Sao Joao Del Rei, MG - Brazil

^[3] Itauna Univ, Undergrad Course Nutr, BR-35680142 Itauna, MG - Brazil

^[4] Itauna Univ, Undergrad Course Nursing, BR-35680142 Itauna, MG - Brazil

^[5] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Social Med, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: NUTRIENTS; v. 13, n. 6 JUN 2021.
• Web of Science Citations: 1

Abstract

Excessive body fat at birth is a risk factor for the development of childhood obesity. The aim of the present systematic review with meta-analysis was to evaluate the effect of lifestyle interventions in pregnant women with overweight or obesity on neonatal adiposity. The PubMed, Embase, Web of Science, Scopus, and LILACS databases were used as information sources. Original articles from randomized clinical trials of lifestyle intervention studies on pregnant women with excessive body weight and the effect on neonatal adiposity were considered eligible. The risk of bias was assessed using Cochrane criteria. The meta-analysis was calculated using the inverse variance for continuous data expressed as mean difference (MD), using the random effect model with a 95% confidence interval (CI). The outcomes were submitted to the GRADE evaluation. Of 2877 studies, four were included in the qualitative and quantitative synthesis (n = 1494). All studies were conducted in developed countries, with three including pregnant women with overweight or obesity, and one only pregnant women with obesity. The interventions had no effect on neonatal adiposity {[}Heterogeneity = 56%, MD = -0.21, CI = (-0.92, 0.50)] with low confidence in the evidence, according to GRADE. Studies are needed in low- and medium-developed countries with different ethnic-racial populations. PROSPERO (CRD42020152489). (AU)

• FAPESP's process: 17/18980-2 - Adherence to the goals of a lifestyle intervention among overweight pregnant women and its effect on perinatal outcomes
• Grantee: Lívia Castro Crivellenti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral