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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications

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Author(s):
de Almeida Chuffa, Luiz Gustavo [1] ; Ferreira Seiva, Fabio Rodrigues [2] ; Novais, Adriana Alonso [3] ; Simao, Vinicius Augusto [1] ; Martin Gimenez, Virna Margarita [4] ; Manucha, Walter [5, 6] ; Pires de Campos Zuccari, Debora Aparecida [7] ; Reiter, Russel J. [8]
Total Authors: 8
Affiliation:
[1] UNESP Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, BR-18618689 Botucatu, SP - Brazil
[2] Univ Estadual Norte Parana UENP, Biol Sci Ctr, Dept Biol, Luiz Meneghel Campus, BR-86360000 Bandeirantes, PR - Brazil
[3] Univ Fed Mato Grosso, Hlth Sci Inst, UFMT, BR-78607059 Sinop, MG - Brazil
[4] Univ Catolica Cuyo, Fac Ciencias Quim & Tecnol, Inst Invest Ciencias Quim, RA-5400 Sede San Juan - Argentina
[5] Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol, Lab Farmacol Expt Bas & Traslac, Area Farmacol, RA-5500 Mendoza - Argentina
[6] Consejo Nacl Invest Cient & Tecnol IMBECU CONICET, Inst Med & Biol Expt Cuyo, RA-5500 Mendoza - Argentina
[7] FAMERP, Canc Mol Res Lab LIMC, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto - Brazil
[8] UT Health, Dept Cell Syst & Anat, San Antonio, TX 78229 - USA
Total Affiliations: 8
Document type: Review article
Source: Molecules; v. 26, n. 12 JUN 2021.
Web of Science Citations: 0
Abstract

The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamine) is a small indoleamine secreted essentially by the pineal gland during darkness, but also produced by most cells in a non-circadian manner from which it is not released into the blood. Although the therapeutic promise of melatonin is indisputable, aspects regarding optimal dosage, biotransformation and metabolism, route and time of administration, and targeted therapy remain to be examined for proper treatment results. Recently, prolonged release of melatonin has shown greater efficacy and safety when combined with a nanostructured formulation. This review summarizes the role of melatonin incorporated into different nanocarriers (e.g., lipid-based vesicles, polymeric vesicles, non-ionic surfactant-based vesicles, charge carriers in graphene, electro spun nanofibers, silica-based carriers, metallic and non-metallic nanocomposites) as drug delivery system platforms or multilevel determinations in various in vivo and in vitro experimental conditions. Melatonin incorporated into nanosized materials exhibits superior effectiveness in multiple diseases and pathological processes than does free melatonin; thus, such information has functional significance for clinical intervention. (AU)

FAPESP's process: 19/00906-6 - Melatonin and the MT1 and MT2 receptors: effects on apoptosis, cell proliferation and migratory potential of the ovarian carcinoma cells (SKOV-3 cell line)
Grantee:Luiz Gustavo de Almeida Chuffa
Support Opportunities: Regular Research Grants