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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria

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Author(s):
Roque-Borda, Cesar Augusto [1] ; da Silva, Patricia Bento [2] ; Rodrigues, Mosar Correa [2] ; Azevedo, Ricardo Bentes [2] ; Di Filippo, Leonardo [3] ; Duarte, Jonatas L. [3] ; Chorilli, Marlus [3] ; Vicente, Eduardo Festozo [4] ; Pavan, Fernando Rogerio [1]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, TB Res Lab, BR-14800903 Araraquara, SP - Brazil
[2] Univ Brasilia, Inst Biol Sci, Dept Genet & Morphol, Lab Nanobiotechnol, BR-70910900 Brasilia, DF - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, BR-14800903 Araraquara, SP - Brazil
[4] Sao Paulo State Univ UNESP, Sch Sci & Engn, BR-17602496 Tupa - Brazil
Total Affiliations: 4
Document type: Review article
Source: PHARMACEUTICS; v. 13, n. 6 JUN 2021.
Web of Science Citations: 1
Abstract

Bacterial resistance has intensified in recent years due to the uncontrolled use of conventional drugs, and new bacterial strains with multiple resistance have been reported. This problem may be solved by using antimicrobial peptides (AMPs), which fulfill their bactericidal activity without developing much bacterial resistance. The rapid interaction between AMPs and the bacterial cell membrane means that the bacteria cannot easily develop resistance mechanisms. In addition, various drugs for clinical use have lost their effect as a conventional treatment; however, the synergistic effect of AMPs with these drugs would help to reactivate and enhance antimicrobial activity. Their efficiency against multi-resistant and extensively resistant bacteria has positioned them as promising molecules to replace or improve conventional drugs. In this review, we examined the importance of antimicrobial peptides and their successful activity against critical and high-priority bacteria published in the WHO list. (AU)

FAPESP's process: 20/16573-3 - In vitro and in vivo studies of antimicrobial peptide B1CTcu5 analogs encapsulated in colon-specific microparticles against Mycobacterium tuberculosis
Grantee:Cesar Augusto Roque Borda
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/25707-3 - Application of the antimicrobial peptide Ctx(Ile21)-Ha and its conjugates in different formulations as a nutritional additive in laying hens
Grantee:Cesar Augusto Roque Borda
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 20/13497-4 - Search for the mechanism of action and therapeutic effect of new classes of drugs against Mycobacterium tuberculosis
Grantee:Fernando Rogério Pavan
Support Opportunities: Regular Research Grants