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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diagnostic tools for neurosyphilis: a systematic review

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Author(s):
Boog, Gustavo Henrique Pereira [1] ; Lopes, Joao Vitor Ziroldo [1] ; Mahler, Joao Vitor [1] ; Solti, Marina [1] ; Kawahara, Lucas Tokio [1] ; Teng, Andre Kakinoki [1] ; Munhoz, Joao Victor Taba [1] ; Levin, Anna S. [2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Infect Control Dept, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: BMC INFECTIOUS DISEASES; v. 21, n. 1 JUN 14 2021.
Web of Science Citations: 0
Abstract

Purpose: Increasing incidences of syphilis highlight the preoccupation with the occurrence of neurosyphilis. This study aimed to understand the current diagnostic tools and their performance to detect neurosyphilis, including new technologies and the variety of existing methods. Methods: We searched databases to select articles that reported neurosyphilis diagnostic methods and assessed their accuracy, presenting sensitivity and specificity values. Information was synthesized in tables. The risk of bias was examined using the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy recommendations. Results: Fourteen studies were included. The main finding was a remarkable diversity of tests, which had varied purposes, techniques, and evaluation methodologies. There was no uniform criterion or gold standard to define neurosyphilis. The current basis for its diagnosis is clinical suspicion and cerebrospinal fluid analysis. There are new promising tests such as PCR tests and chemokine measurement assays. Conclusions: The diagnosis of neurosyphilis is still a challenge, despite the variety of existing and developing tests. We believe that the multiplicity of reference standards adopted as criteria for diagnosis reveals the imprecision of the current definitions of neurosyphilis. An important next step for the scientific community is to create a universally accepted diagnostic definition for this disease. (AU)

FAPESP's process: 19/18441-0 - Investigation of neurosyphilis and clinical parameters in HIV-negative patients with latent syphilis
Grantee:Gustavo Henrique Pereira Boog
Support Opportunities: Scholarships in Brazil - Scientific Initiation