Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intestinal GLUT5 and FAT/CD36 transporters and blood glucose are reduced by a carotenoid/MUFA-rich oil in high-fat fed mice

Full text
Author(s):
Evangelista-Silva, Paulo Henrique [1, 2] ; Prates, Rodrigo Pereira [1] ; Leite, Jaqueline Santos Moreira [2] ; Moreno, Lauane Gomes [1] ; Goulart-Silva, Francemilson [2] ; Esteves, Elizabethe Adriana [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Vales Jequitinhonha & Mucuri UFVJM, Programa Posgrad Multictr Ciencias Fisiol, Fac Biol & Hlth Sci, Rodovia MGT 367, Km 583 5000, BR-39100000 Diamantina, MG - Brazil
[2] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Av Prof Dr Lineu Prestes 1524, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Life Sciences; v. 279, AUG 15 2021.
Web of Science Citations: 0
Abstract

Aims: Intestinal nutrient absorption plays a vital role in developing obesity, and nutrient transporters expressed in the enterocytes facilitate this process. Moreover, previous studies have shown that specific foods and diets can affect their cell levels. Herein, we investigated the effects of pequi oil (PO), which is high in several bioactive compounds, on intestinal nutrient transporter levels as well as on intestinal morphology and metabolic biomarkers. Main methods: Groups of male C57BL/6 mice were fed either a standard (C) or a high-fat diet (HFD) and pequi oil (CP and HFDP with PO by gavage at 150 mg/day) for eight weeks. Food intake and body weight were monitored, serum metabolic biomarkers, intestinal transporter levels and histological analyses were performed. Key findings: PO increased caloric intake without increasing body or fat mass regardless of diet. The HFD group treated with PO reduced fasting blood glucose and villus width. PO did not affect GLUT2, L-FABP, FATP4, NPC1L1, NHE3 or PEPT1 content in CP or HFDP groups. GLUT5 and FAT/CD36 levels were reduced in both CP and HFDP. Significance: Our data suggest that PO attenuated monosaccharide and fatty acid absorption, contributing to lower fasting glycemia and higher food intake without affecting body weight or visceral fat of high-fat feed mice. (AU)

FAPESP's process: 14/12871-9 - Repercussions of the high fat diet chronic intake on the mechanisms of nutrients transport of enterocytes: evaluation of the involvement of thyroid hormones in these processes
Grantee:Francemilson Goulart da Silva
Support Opportunities: Regular Research Grants