Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Klotho genetic variants mediate the association between obstructive sleep apnea and short telomere length

Full text
Author(s):
Tempaku, Priscila Farias [1] ; D'Almeida, Vania [1] ; Affonso da Silva, Sylvia Maria [1] ; Andersen, Monica Levy [1] ; Belangero, Sintia Iole [2] ; Tufik, Sergio [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol & Morfol Genet, Sao Paulo - Brazil
[2] Univ Fed Sao Poulo, Morfol & Genet, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Sleep Medicine; v. 83, p. 210-213, JUL 2021.
Web of Science Citations: 0
Abstract

The core features of obstructive sleep apnea (OSA) can potentially contribute to the acceleration of telomere shortening mechanisms. Other factor associated with telomeres is Klotho gene as it can negatively regulates telomerase activity. Noteworthy, KLOTHO protein level has recently been associated with OSA. In this sense, it was plausible to hypothesize that OSA would be associated with short telomere length and those with OSA plus risk single nucleotide polymorphisms (SNPs) in Klotho gene would present even shorter telomere length. As part of the EPISONO cohort, 1042 individuals answered questionnaires, underwent polysomnography and had blood collected for DNA extraction. OSA was defined according to AHI >= 15 events/hour. Leukocyte telomere length (LTL) was measured through realtime polymerase chain reaction (qPCR) and Klotho SNPs were genotyped by array. Mediation analyses considered the presence of SNPs in Klotho gene and how this interaction can affect OSA and its consequence in telomere length. All the analyses were corrected for multiple comparisons. LTL was significantly shorter in OSA compared to controls in a severity-dependent manner (B = 0.055; CI = 0.007 -0.102; p = 0.02). Among the 43 Klotho SNPs analyzed, we observed that 4 SNPs (rs525014, rs7982726, rs685417 and rs9563124) significantly mediated the association between OSA and short LTL. Klotho gene opens a new venue in OSA research since it can contribute in the increase of knowledge of the mechanisms involved in the consequences of short telomeres in individuals with OSA. (C) 2021 Published by Elsevier B.V. (AU)

FAPESP's process: 18/00955-4 - Study of the effect of obstructive sleep apnea on the telomere length and its associated mechanisms
Grantee:Priscila Farias Tempaku
Support Opportunities: Scholarships in Brazil - Doctorate