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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system

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Author(s):
Cruz, Paula L. [1] ; Moraes-Silva, Ivana C. [1] ; Ribeiro, Amanda A. [1] ; Machi, Jacqueline F. [1] ; de Melo, Marcelo Dantas Tavares [1] ; dos Santos, Fernando [1] ; da Silva, Maikon Barbosa [1] ; Strunz, Celia Maria Cassaro [1] ; Caldini, Elia Garcia [2] ; Irigoyen, Maria-Claudia [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Av Dr Eneas Carvalho Aguiar, 44 Bloco 1, BR-05403900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BMC Endocrine Disorders; v. 21, n. 1 JUN 28 2021.
Web of Science Citations: 0
Abstract

Background To evaluate the effect of nicotinamide prior to streptozotocin-induced (STZ) diabetes in baroreflex sensitivity and cardiovascular autonomic modulation, and its association with hemodynamics and metabolic parameters. Methods Methods: Male Wistar rats were divided into control (Cont) and STZ-induced diabetes (Diab). Half of the rats from each group received a single dose of nicotinamide (100 mg/Kg) before STZ injection (Cont+NicA and Diab+NicA). All groups were followed-up for 5 weeks. Results Body weight loss of more than 40% was observed in Diab throughout the period (Diab: 271.00 +/- 12.74 g; Diab+NicA: 344.62 +/- 17.82). Increased glycemia was seen in Diab rats (541.28 +/- 18.68 mg/dl) while Diab+NicA group had a slight decrease (440.87 +/- 20.96 mg/dl). However, insulin resistance was observed only in Diab. In relation to Cont, heart rate, mean blood pressure and diastolic function were reduced when compared to Diab, together with parasympathetic modulation and baroreflex sensitivity. All of these parameters were improved in Diab+NicA when compared to Diab. Improved baroreflex sensitivity and parasympathetic modulation were correlated with glycemia, insulin resistance, and body weight mass. Additionally, Diab+NicA group increased survival rate. Conclusions Results suggest that the association of nicotinamide in STZ-induced diabetic rats prevents most of the expected derangements mainly by preserving parasympathetic and baroreflex parameters. (AU)

FAPESP's process: 12/20262-7 - Resveratrol action on proteoglycans membrane present in heart muscle in an animal model of diabetic cardiomyopathy
Grantee:Celia Maria Cassaro Strunz
Support Opportunities: Regular Research Grants