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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

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Author(s):
Baptista, Mauricio S. [1] ; Cadet, Jean [2] ; Greer, Alexander [3, 4] ; Thomas, Andres H. [5]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Sao Paulo - Brazil
[2] Univ Sherbrooke, Dept Med Nucl & Radiobiol, Sherbrooke, PQ - Canada
[3] Brooklyn Coll, Dept Chem, Brooklyn, NY - USA
[4] CUNY, Grad Ctr, PhD Program Chem, New York, NY 10010 - USA
[5] Univ Nacl La Plata UNLP, Fac Ciencias Exactas, Inst Invest Fisicoquim Teor & Aplicades INIFTA, Dept Quim, CCT La Plata CONICET, La Plata - Argentina
Total Affiliations: 5
Document type: Review article
Source: Photochemistry and Photobiology; v. 97, n. 6, SI JUL 2021.
Web of Science Citations: 13
Abstract

Photosensitization reactions have been demonstrated to be largely responsible for the deleterious biological effects of UV and visible radiation, as well as for the curative actions of photomedicine. A large number of endogenous and exogenous photosensitizers, biological targets and mechanisms have been reported in the past few decades. Evolving from the original definitions of the type I and type II photosensitized oxidations, we now provide physicochemical frameworks, classifications and key examples of these mechanisms in order to organize, interpret and understand the vast information available in the literature and the new reports, which are in vigorous growth. This review surveys in an extended manner all identified photosensitization mechanisms of the major biomolecule groups such as nucleic acids, proteins, lipids bridging the gap with the subsequent biological processes. Also described are the effects of photosensitization in cells in which UVA and UVB irradiation triggers enzyme activation with the subsequent delayed generation of superoxide anion radical and nitric oxide. Definitions of photosensitized reactions are identified in biomolecules with key insights into cells and tissues. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC