Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

Author(s)

Pral, Lais P. ^[1] ; Fachi, Jose L. ^{[2, 1]} ; Correa, Renan O. ^[1] ; Colonna, Marco ^[2] ; Vinolo, Marco A. R. ^{[1, 3, 4]}

Affiliation

^[1] Univ Estadual Campinas, Inst Biol, Dept Genet & Evolut Microbiol & Immunol, Lab Immunoinflammat, Campinas - Brazil

^[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 - USA

^[3] Expt Med Res Cluster, Campinas - Brazil

^[4] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas - Brazil

• Document type: Review article
• Source: TRENDS IN IMMUNOLOGY; v. 42, n. 7, p. 604-621, JUL 2021.
• Web of Science Citations: 0

Abstract

Oxygen (O2) availability is a key factor regulating microbiota composition and the homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiotaderived metabolites increase O2 consumption by intestinal epithelial cells (IECs), reducing its availability in the gut and leading to hypoxia. This physiological hypoxia activates cellular hypoxic sensors that adapt the metabolism and function of IECs and mucosa-resident cells, such as type-3 innate lymphoid cells (ILC3s). In this review, we discuss recent evidence suggesting that the intricate and multidirectional interactions among the microbiota, hypoxia/hypoxic sensors, and mammalian host cells (IECs and ILC3s) determine how the intestinal barrier and host-microbiota-pathogens connections are molded. Understanding these interactions might provide new treatment possibilities for dysbiosis, as well as certain inflammatory and infectious diseases. (AU)

• FAPESP's process: 16/23142-3 - Interaction between HIF-1 and short-chain fatty acids in the intestine: what is the role of HIF-1 acetylation?
• Grantee: Renan Oliveira Corrêa
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/06577-9 - Mechanisms involved in the protective effect of short-chain fatty acids against Clostridium difficile-associated colitis
• Grantee: José Luís Fachi
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/02208-1 - Effect of short chain fatty acids on the function of type 3 innate lymphoid cells: involvement of the FFAR2 receptor in this process
• Grantee: Laís Passariello Pral
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/15313-8 - Investigation of the molecular mechanisms involved in the interaction between microbiota-derived metabolites and host cells during inflammation
• Grantee: Marco Aurélio Ramirez Vinolo
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2