| Full text | |
| Author(s): Show less - |
Kagan, Simao
[1, 2]
;
Cogo-Moreira, Hugo
[1]
;
Barbosa, Matheus Ghossain
[1]
;
Cavalcante, Daniel
[1, 3]
;
Shinji, Andre
[1, 3]
;
Noto, Mariane
[3]
;
Haguiara, Bernardo
[1, 2]
;
Cordeiro, Quirino
[1]
;
Belangeiro, Sintia
[4, 1]
;
Bressan, Rodrigo A.
[1, 2, 5]
;
Noto, Cristiano
[1, 2, 3, 5]
;
Gadelha, Ary
[1, 2, 3, 5]
Total Authors: 12
|
| Affiliation: | [1] Fed Univ Sao Paulo EPM UNIFESP, Dept Psychiat, Lab Integrat Neurosci LiNC, Sao Paulo - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Schizophrenia Program PROESQ, Sao Paulo - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Early Psychosis Grp GAPI, Sao Paulo - Brazil
[4] Fed Univ Sao Paulo Unifesp, Dept Morphol & Genet, Sao Paulo - Brazil
[5] Fed Univ Sao Paulo UNIFESP, Ctr Res & Innovat Prevent Mental Disorders & Drug, Dept Psychiat, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | EARLY INTERVENTION IN PSYCHIATRY; JUL 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Aim Construct stability over time is required for reliable inference, but evidence regarding the longitudinal invariance of negative symptoms is still limited. Thus, we examined the longitudinal invariance of the negative dimension using the positive and negative syndrome scale (PANSS) in an antipsychotic-naive first-episode schizophrenia sample at baseline and after 10 weeks. Methods Our study was conducted at a specialized early intervention service. PANSS ratings were analysed for 138 patients, and two different models were specified and tested: a unidimensional and a two-correlated factor solution. Results The unidimensional model fulfilled criteria for longitudinal invariance, whilst the two-correlated did not. Conclusion Our study provides support for the PANSS negative unidimensional model use to evaluate negative symptoms' longitudinal change following first-episode schizophrenia. (AU) | |
| FAPESP's process: | 14/07280-1 - Search for genetic markers of risk, progression and response to treatment |
| Grantee: | Síntia Iole Nogueira Belangero |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/25016-8 - Investigation of the treatment response of schizophrenia with risperidone: a pharmacogenetics study in a cohort of first episode of psychosis patients |
| Grantee: | Síntia Iole Nogueira Belangero |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/08968-6 - Investigation of genetic and epigenetic markers: a translational approach for schizophrenia treatment |
| Grantee: | Síntia Iole Nogueira Belangero |
| Support Opportunities: | Regular Research Grants |