| Full text | |
| Author(s): |
de Oliveira, Marcos Antonio
[1]
;
Tairum, Carlos A.
[2]
;
Soares Netto, Luis Eduardo
[2]
;
Pires de Oliveira, Ana Laura
[1]
;
Aleixo-Silva, Rogerio Luis
[2]
;
Montanhero Cabrera, Vitoria Isabela
[1]
;
Breyer, Carlos A.
[1]
;
dos Santos, Melina Cardoso
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Estadual Paulista, UNESP, Campus Litoral Paulista, BR-11330900 Sao Vicente - Brazil
[2] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, BR-05508090 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | Applied Microbiology and Biotechnology; v. 105, n. 14-15 JUL 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
The oxidative and nitrosative responses generated by animals and plants are important defenses against infection and establishment of pathogenic microorganisms such as bacteria, fungi, and protozoa. Among distinct oxidant species, hydroperoxides are a group of chemically diverse compounds that comprise small hydrophilic molecules, such as hydrogen peroxide and peroxynitrite, and bulky hydrophobic species, such as organic hydroperoxides. Peroxiredoxins (Prx) are ubiquitous enzymes that use a highly reactive cysteine residue to decompose hydroperoxides and can also perform other functions, like molecular chaperone and phospholipase activities, contributing to microbial protection against the host defenses. Prx are present in distinct cell compartments and, in some cases, they can be secreted to the extracellular environment. Despite their high abundance, Prx expression can be further increased in response to oxidative stress promoted by host defense systems, by treatment with hydroperoxides or by antibiotics. In consequence, some isoforms have been described as virulence factors, highlighting their importance in pathogenesis. Prx are very diverse and are classified into six different classes (Prx1-AhpC, BCP-PrxQ, Tpx, Prx5, Prx6, and AhpE) based on structural and biochemical features. Some groups are absent in hosts, while others present structural peculiarities that differentiate them from the host's isoforms. In this context, the intrinsic characteristics of these enzymes may aid the development of new drugs to combat pathogenic microorganisms. Additionally, since some isoforms are also found in the extracellular environment, Prx emerge as attractive targets for the production of diagnostic tests and vaccines. (AU) | |
| FAPESP's process: | 20/00845-4 - Unraveling the biological role of LsfA, a 1-Cys Prx involved in the P. aeruginosa virulence |
| Grantee: | Rogério Luis Aleixo Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/06263-4 - Evaluation of bioactive molecules as inhibitors for atioxidant system of typical 2-Cys peroxiredoxins (AhpC) in baceria |
| Grantee: | Melina Cardoso dos Santos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 20/02868-1 - Effects of natural compounds over the peroxidase activity of AhpCs and pathogenic bacteria survival |
| Grantee: | Vitória Isabela Montanhero Cabrera |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 16/15849-0 - Connecting structural and biochemical aspects of peroxiredoxins to cell signaling processes and proteic quality control |
| Grantee: | Carlos Abrunhosa Tairum Junior |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 11/13500-6 - Investigation of the molecular determinants involved in the interaction with substrates of Tsa1 and Tsa2 of Saccharomyces cerevisiae |
| Grantee: | Carlos Alexandre Breyer |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/19942-7 - Search for inhibitors of the peroxirredoxin system from pathogens and humans |
| Grantee: | Marcos Antonio de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/04054-4 - Search of inhibitors of typical 2-Cys peroxirredoxin system from eukaryotes: functional and structural evaluation |
| Grantee: | Ana Laura Pires de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Master |