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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relevance of peroxiredoxins in pathogenic microorganisms

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Author(s):
de Oliveira, Marcos Antonio [1] ; Tairum, Carlos A. [2] ; Soares Netto, Luis Eduardo [2] ; Pires de Oliveira, Ana Laura [1] ; Aleixo-Silva, Rogerio Luis [2] ; Montanhero Cabrera, Vitoria Isabela [1] ; Breyer, Carlos A. [1] ; dos Santos, Melina Cardoso [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista, UNESP, Campus Litoral Paulista, BR-11330900 Sao Vicente - Brazil
[2] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, BR-05508090 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Applied Microbiology and Biotechnology; v. 105, n. 14-15 JUL 2021.
Web of Science Citations: 0
Abstract

The oxidative and nitrosative responses generated by animals and plants are important defenses against infection and establishment of pathogenic microorganisms such as bacteria, fungi, and protozoa. Among distinct oxidant species, hydroperoxides are a group of chemically diverse compounds that comprise small hydrophilic molecules, such as hydrogen peroxide and peroxynitrite, and bulky hydrophobic species, such as organic hydroperoxides. Peroxiredoxins (Prx) are ubiquitous enzymes that use a highly reactive cysteine residue to decompose hydroperoxides and can also perform other functions, like molecular chaperone and phospholipase activities, contributing to microbial protection against the host defenses. Prx are present in distinct cell compartments and, in some cases, they can be secreted to the extracellular environment. Despite their high abundance, Prx expression can be further increased in response to oxidative stress promoted by host defense systems, by treatment with hydroperoxides or by antibiotics. In consequence, some isoforms have been described as virulence factors, highlighting their importance in pathogenesis. Prx are very diverse and are classified into six different classes (Prx1-AhpC, BCP-PrxQ, Tpx, Prx5, Prx6, and AhpE) based on structural and biochemical features. Some groups are absent in hosts, while others present structural peculiarities that differentiate them from the host's isoforms. In this context, the intrinsic characteristics of these enzymes may aid the development of new drugs to combat pathogenic microorganisms. Additionally, since some isoforms are also found in the extracellular environment, Prx emerge as attractive targets for the production of diagnostic tests and vaccines. (AU)

FAPESP's process: 20/00845-4 - Unraveling the biological role of LsfA, a 1-Cys Prx involved in the P. aeruginosa virulence
Grantee:Rogério Luis Aleixo Silva
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/06263-4 - Evaluation of bioactive molecules as inhibitors for atioxidant system of typical 2-Cys peroxiredoxins (AhpC) in baceria
Grantee:Melina Cardoso dos Santos
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 20/02868-1 - Effects of natural compounds over the peroxidase activity of AhpCs and pathogenic bacteria survival
Grantee:Vitória Isabela Montanhero Cabrera
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/15849-0 - Connecting structural and biochemical aspects of peroxiredoxins to cell signaling processes and proteic quality control
Grantee:Carlos Abrunhosa Tairum Junior
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/13500-6 - Investigation of the molecular determinants involved in the interaction with substrates of Tsa1 and Tsa2 of Saccharomyces cerevisiae
Grantee:Carlos Alexandre Breyer
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/19942-7 - Search for inhibitors of the peroxirredoxin system from pathogens and humans
Grantee:Marcos Antonio de Oliveira
Support type: Regular Research Grants
FAPESP's process: 19/04054-4 - Search of inhibitors of typical 2-Cys peroxirredoxin system from eukaryotes: functional and structural evaluation
Grantee:Ana Laura Pires de Oliveira
Support type: Scholarships in Brazil - Master