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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytotoxic T-lymphocyte-associated protein 4 in gastric cancer: Prognosis and association with PD-L1 expression

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Author(s):
Pereira, Marina Alessandra [1] ; de Castria, Tiago Biachi [1] ; Kodama Pertille Ramos, Marcus Fernando [1] ; Dias, Andre Roncon [1] ; Cardili, Leonardo [1] ; Rodrigues Moraes, Rafael Dyer [1] ; Zilberstein, Bruno [1] ; Nahas, Sergio Carlos [1] ; Ribeiro Jr, Ulysses ; de Mello, Evandro Sobroza [2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Dept Gastroenterol, Hosp Clin HCFMUSP, Dept Pathol, Sao Paulo - Brazil
[2] Ribeiro Jr, Jr., Ulysses, Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Dept Gastroenterol, Hosp Clin HCFMUSP, Dept Pathol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF SURGICAL ONCOLOGY; v. 124, n. 7 JUL 2021.
Web of Science Citations: 0
Abstract

Background Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is one of the most studied immune checkpoint in gastric cancer (GC). However, the prognostic role of CTLA-4 expression in GC is poorly described. This study aimed to evaluate CTLA-4 expression in GC and its impact on survival, including patients treated with standard platinum-based chemotherapy (CMT), and association with PD-L1 expression. Methods All GC patients who underwent D2-gastrectomy were investigated retrospectively. Tumor samples were examined for CTLA-4 and PD-L1 by immunohistochemistry. Tumor-infiltrating inflammatory cells, including CD4 + and CD8 + , were also examined. Results Among the 284 GC patients included, 159 (56%) were CTLA-4 positive and the remaining 125 (44%) were classified as negative. CTLA-4 positive GC was associated with increased inflammatory cell infiltration (p < 0.001), high CD8 + T cells (p = 0.016) and PD-L1 expression (p = 0.026). Considering GC referred for treatment, CTLA-4 negative patients who received CMT had a significant improvement in disease-free survival compared to untreated CLTA-4 negative (p = 0.028). In multivariate analysis, GC positive for both CTLA-4 and PD-L1 had a prognostic impact on survival. Conclusion CTLA-4 positive was associated with PD-L1 expression and a high tumor-infiltrating CD8 + T cells. Accordingly, positivity for both CTLA-4 and PD-L1 was an independent factor associated to better survival in GC patients. (AU)

FAPESP's process: 16/25524-0 - Characterization of Helicobacter pylori infection, Epstein-Barr virus and gene-protein expression profile in gastric adenocarcinomas
Grantee:Ulysses Ribeiro Júnior
Support Opportunities: Regular Research Grants