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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of physical activity on vascular function in autoimmune rheumatic diseases: a systematic review and meta-analysis

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Author(s):
Pecanha, Tiago [1, 2] ; Bannell, Daniel J. [3] ; Sieczkowska, Sofia Mendes [1, 2] ; Goodson, Nicola [4] ; Roschel, Hamilton [1, 2] ; Sprung, Victoria S. [3] ; Low, David A. [3]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Appl Physiol & Nutr Res Grp, Sch Phys Educ & Sport, Sao Paulo - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Lab Assessment & Conditioning Rheumatol, Rheumatol, Sao Paulo - Brazil
[3] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside - England
[4] Liverpool Univ Hosp NHS Fdn Trust, Aintree Univ Hosp, Liverpool, Merseyside - England
Total Affiliations: 4
Document type: Review article
Source: RHEUMATOLOGY; v. 60, n. 7, p. 3107-3120, JUL 2021.
Web of Science Citations: 1
Abstract

Objectives. To summarize existing evidence and quantify the effects of physical activity on vascular function and structure in autoimmune rheumatic diseases (ARDs). Methods. Databases were searched (through March 2020) for clinical trials evaluating the effects of physical activity interventions on markers of micro- and macrovascular function and macrovascular structure in ARDs. Studies were combined using random effects meta-analysis, which was conducted using Hedges' g. Meta-analyses were performed on each of the following outcomes: microvascular function {[}i.e. skin blood flow or vascular conductance responses to acetylcholine (ACh) or sodium nitropusside (SNP) administration]; macrovascular function {[}i.e. brachial flow-mediated dilation (FMD%) or brachial responses to glyceryl trinitrate (GTN%); and macrovascular structure {[}i.e. aortic pulse wave velocity (PWV)]. Results. Ten studies (11 trials) with a total of 355 participants were included in this review. Physical activity promoted significant improvements in microvascular {[}skin blood flow responses to ACh, g=0.92 (95% CI 0.42, 1.42)] and macrovascular function {[}FMD%, g=0.94 (95% CI 0.56, 1.02); GTN%, g=0.53 (95% CI 0.09, 0.98)]. Conversely, there was no evidence for beneficial effects of physical activity on macrovascular structure {[}PWV, g=-0.41 (95% CI -1.13, 0.32)]. Conclusions. Overall, the available clinical trials demonstrated a beneficial effect of physical activity on markers of micro- and macrovascular function but not on macrovascular structure in patients with ARDs. The broad beneficial impact of physical activity across the vasculature identified in this review support its role as an effective non-pharmacological management strategy for patients with ARDs. (AU)

FAPESP's process: 19/15231-4 - Promotion of healthy lifestyle in patients with Systemic Erythematosus Lupus: effects on cardiometabolic risks factors the randomized and controlled clinical trial living well with Lupus
Grantee:Sofia Mendes Sieczkowska
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/07150-4 - Breaking up sedentary time in rheumatoid arthritis: effects on vascular function
Grantee:Tiago Peçanha de Oliveira
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 16/23319-0 - Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time
Grantee:Tiago Peçanha de Oliveira
Support Opportunities: Scholarships in Brazil - Post-Doctoral