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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking

Full text
Author(s):
Tavares, Lucas A. [1] ; Januario, Yunan C. [1] ; daSilva, Luis L. P. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cell & Mol Biol, Ctr Virol Res, Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Review article
Source: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 9, JUL 8 2021.
Web of Science Citations: 0
Abstract

The human immunodeficiency virus (HIV-1) modifies the host cell environment to ensure efficient and sustained viral replication. Key to these processes is the capacity of the virus to hijack ATPases, GTPases and the associated proteins that control intracellular protein trafficking. The functions of these energy-harnessing enzymes can be seized by HIV-1 to allow the intracellular transport of viral components within the host cell or to change the subcellular distribution of antiviral factors, leading to immune evasion. Here, we summarize how energy-related proteins deviate from their normal functions in host protein trafficking to aid the virus in different phases of its replicative cycle. Recent discoveries regarding the interplay among HIV-1 and host ATPases and GTPases may shed light on potential targets for pharmacological intervention. (AU)

FAPESP's process: 17/12022-0 - Characterization of the molecular mechanisms used by Arc protein to modify the intracellular traffic and processing of AMPA receptors and beta-amyloid precursor protein (APP)
Grantee:Yunan Costa Januário
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/00297-7 - Study of the effects of HIV-1 Nef on the host-cell endomembrane system and their implications in viral pathogenesis
Grantee:Luis Lamberti Pinto da Silva
Support Opportunities: Regular Research Grants
FAPESP's process: 16/18207-9 - Characterization of protein trafficking pathways involved in lysosome biogenesis and function in human cells
Grantee:Lucas Alves Tavares
Support Opportunities: Scholarships in Brazil - Doctorate