EGFRvIII peptide nanocapsules and bevacizumab nanocapsules: a nose-to-brain multitarget approach against glioblastoma

Author(s):Show less -

de Cristo Soares Alves, Aline ^[1] ; Lavayen, Vladimir ^[2] ; de Fraga Dias, Amanda ^{[1, 3]} ; Bruinsmann, Franciele Aline ; Scholl, Juliete Nathali ^[3] ; Ce, Rodrigo ; Visioli, Fernanda ^{[4, 5]} ; Oliveira Battastini, Ana Maria ^{[3, 6]} ; Staniscuaski Guterres, Silvia ^[1] ; Figueiro, Fabricio ^{[3, 6]} ; Raffin Pohlmann, Adriana ^[1]

Affiliation

^[1] Univ Fed Rio Grande, Programas Graduacoa Ciencias Farmac, Fac Farmacia, Av Ipiranga, 2752, BR-90610 Porto Alegre, RS - Brazil

^[2] Univ Fed Rio Grande, Inst Quimica, Dept Quimica Inorganica, Av Bento Goncalves, 9500, BR-91501970 Porto Alegre, RS - Brazil

^[3] Univ Fed Rio Grande, Inst Ciencias, Programas Graduacoa Ciencias Biolo, Rua Ramiro Barcelos, BR-2600 Porto Alegre, RS 90035003 - Brazil

^[4] Univ Fed Rio Grande, Programas Graduacoa Odontologia, Faculdade Odontologia, Rua Ramiro Barcelos, 2492, BR-90035 Porto Alegre, RS - Brazil

^[5] Hosp Clin Porto Alegre, Ctr Pesquisa Expt, Rua Ramiro Barcelos, 2350, BR-90035903 Porto Alegre, RS - Brazil

^[6] Univ Fed Rio Grande, Inst Ciencias, Dept Bioquimica, Rua Ramiro Barcelos, 2600, BR-90035 Porto Alegre, RS - Brazil

• Document type: Journal article
• Source: Nanomedicine; v. 16, n. 20, p. 1775-1790, AUG 2021.
• Web of Science Citations: 0

Abstract

Aim: To evaluate the antitumor efficacy of bevacizumab-functionalized nanocapsules in a rat glioblastoma model after the pretreatment with nanocapsules functionalized with a peptide-specific to the epidermal growth factor receptor variant III. Materials \& methods: Nanocapsules were prepared, physicochemical characterized and intranasally administered to rats. Parameters such as tumor size, histopathological characteristics and infiltration of CD8(+) T lymphocytes were evaluated. Results: The strategy of treatment resulted in a reduction of 87% in the tumor size compared with the control group and a higher infiltration of CD8(+) T lymphocytes in tumoral tissue. Conclusion: The block of two different molecular targets using nose-to-brain delivery represents a new and promising approach against glioblastoma. (AU)

• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support Opportunities: Research Projects - Thematic Grants