| Full text | |
| Author(s): Show less - |
Wagner, Vivian Petersen
[1, 2]
;
Rodrigues-Fernandes, Carla Isabelly
[1]
;
Ribeiro Carvalho, Marcus Vinicius
[1]
;
Santos, Jean Nunes
[3]
;
Barra, Marinez Bizarro
[4]
;
Hunter, Keith D.
[2, 5]
;
Manuel Aguirr-Urizar, Jose
[6]
;
Heerden, Willie F. P.
[5]
;
Vargas, Pablo Agustin
[1, 5]
;
Fonseca, Felipe Paiva
[1, 7, 5]
;
Martins, Manoela Domingues
[8, 1]
Total Authors: 11
|
| Affiliation: | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil
[2] Univ Sheffield, Dept Clin Dent, Acad Unit Oral & Maxillofacial Med & Pathol, Sheffield, S Yorkshire - England
[3] Univ Fed Bahia, Sch Dent, Dept Oral Pathol, Salvador, BA - Brazil
[4] Moinhos de Vento Hosp, Pathol Serv, Porto Alegre, RS - Brazil
[5] Univ Pretoria, Sch Dent, Dept Oral Biol & Pathol, Pretoria - South Africa
[6] Univ Basque Country, EHU, Dept Stomatol 2, Unit Oral Pathol & Med, Leioa - Spain
[7] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil
[8] Univ Fed Rio Grande do Sul, Sch Dent, Dept Pathol, Porto Alegre, RS - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 6, p. 622-630, JUL 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Although uncommon, mature small B-cell lymphomas may arise in the oral/maxillofacial area and oral pathologists must be aware of the key characteristics of these neoplasms to perform an accurate diagnosis. In this manuscript, we attempted to integrate the currently available data on the clinicopathological features of follicular lymphoma (FL), mantle cell lymphoma (MCL), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT-L), and chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL) affecting these anatomical regions. Methods An updated descriptive literature review was carried out and a detailed electronic search was done in multiple databases to gather all cases affecting the oral/maxillofacial region and palatine tonsils. Results We observed that MALT-L was the most frequently reported subtype, followed by FL, MCL, and CLL/SLL. The palate was affected in a high proportion of cases and the most usual clinical presentation was an asymptomatic swelling. MALT-L and CLL/SLL neoplastic cells were strongly associated with small salivary glands. FL showed no gender preference, while MCL and CLL/SLL were more prevalent in males and MALT-L in females. Overall, cases were more common in elderly individuals. Patients' treatment and outcome varied, with MCL being the most aggressive neoplasm with a dismal prognosis in comparison to FL and MALT-L. Conclusion Despite the poor documentation in many of the cases available, especially regarding the microscopic and molecular features of tumors, this review demonstrated that the oral mature small B-cell lymphomas investigated share similar clinical presentation, but carry different prognostic significance, demanding an accurate diagnosis. (AU) | |
| FAPESP's process: | 16/21785-4 - Association of BDNF/TRKB signaling pathway with tumor agressiveness and cancer stem cell profile of malignant salivary gland tumors |
| Grantee: | Vivian Petersen Wagner |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |