Burkitt lymphoma of the head and neck: An international collaborative study

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Arboleda, Lady Paola Aristizabal ^[1] ; Rodrigues-Fernandes, Carla Isabelly ^[1] ; Mariz, Bruno Augusto Linhares Almeida ^[1] ; de Andrade, Bruno Augusto Benevenuto ^[2] ; Abrahao, Aline Correa ^[2] ; Agostini, Michelle ^[2] ; Romanach, Mario Jose ^[2] ; Pontes, Helder Antonio Rebelo ^[3] ; Fonseca, Felipe Paiva ^{[4, 1, 5]} ; Robinson, Liam ^[5] ; van Heerden, Willie F. P. ^[5] ; Carlos, Roman ^[6] ; Tager, Elena Maria Jose Roman ^[1] ; Hoffmann, Iva Loureiro ^[7] ; Cardinalli, Izilda Aparecida ^[7] ; de Mendonca, Regina Maria Holanda ^[7] ; de Vasconcelos Carvalho, Marianne ^[8] ; Martins-de-Barros, Allan Vinicius ^[8] ; Rocha, Andre Caroli ^[9] ; Khurram, Syed Ali ^[10] ; Speight, Paul M. ^[10] ; Lopes, Marcio Ajudarte ^[1] ; Vargas, Pablo Agustin ^{[1, 5]} ; de Almeida, Oslei Paes ^[1] ; Santos-Silva, Alan Roger ^[1]

Affiliation

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Semiol & Oral Pathol, Piracicaba - Brazil

^[2] Univ Fed Rio de Janeiro, Sch Dent, Oral Pathol, Rio De Janeiro - Brazil

^[3] Fed Univ Para, Serv Oral Pathol, Joao de Barros Barreto Univ Hosp, Belem, Para - Brazil

^[4] Univ Fed Minas Gerais, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil

^[5] Univ Pretoria, Sch Dent, Dept Oral Pathol & Oral Biol, Fac Hlth Sci, Pretoria - South Africa

^[6] Hosp Herrera Llerandi, Dept Pathol, Guatemala City - Guatemala

^[7] Boldrini Childrens Ctr, Campinas - Brazil

^[8] Univ Pernambuco, Sch Dent, Recife, PE - Brazil

^[9] Univ Sao Paulo, Sch Med, Clin Hosp, Sao Paulo - Brazil

^[10] Univ Sheffield, Sch Clin Dent, Unit Oral & Maxillofacial Pathol, Sheffield, S Yorkshire - England

• Document type: Journal article
• Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 6, p. 572-586, JUL 2021.
• Web of Science Citations: 0

Abstract

Background Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with three variants (endemic, sporadic, and immunodeficiency-associated), presenting with specific epidemiological and clinical features. Burkitt lymphoma affects the head and neck region (BLHN) in approximately 10% of cases. The aim of this study was to undertake a comparative analysis of the clinicopathologic and immunohistochemical (IHC) features of BLHN diagnosed in patients from Africa, Guatemala, and Brazil. Methods Cases diagnosed as BLHN were collected from the files of six oral pathology laboratory services (Brazil, South Africa, and Guatemala) and one Brazilian pediatric oncology hospital from 1986 to 2020. Clinicopathological and IHC data, and Epstein-Barr virus (EBV) status by in situ hybridization data for each case were reviewed and described. Results Of the 52 cases, BLHN was predominant in pediatric patients {[}43 (82.69%)] and males {[}43 (82.69%)], with a mean age of 11.26 +/- 9.68 years (range, 1-39 years). Neck and cervical lymph nodes {[}14 (26.92%)], and involvement of both maxilla and mandible {[}8 (15.38%)], were the most common anatomical sites. Clinically, tumor/swelling {[}40 (31.25%)], cervical lymphadenopathy {[}14 (10.94%)], pain {[}12 (9.38%)], and bone destruction {[}12 (9.38%)] were frequent findings. All cases showed typical morphological characteristics of BL. IHC profiles included positivity for CD20 {[}52 (100%)], CD10 {[}38 (79.17%)], Bcl6 {[}29 (87.88%)], and c-Myc protein {[}18 (81.82%)]. EBV was positive in 18 cases (62.07%). The Ki-67 index ranged from 90 to 100%. Conclusion The clinicopathological and EBV profile of BLHN in South African, Guatemalan, and Brazilian patients is similar. (AU)

• FAPESP's process: 17/14880-3 - Clinicopathological and immunohistochemical analysis of follicular lymphoid hyperplasias and lymphomas of the oral cavity
• Grantee: Oslei Paes de Almeida
• Support Opportunities: Regular Research Grants