A Review on the Role and Performance of Cellulose Nanomaterials in Sensors

Author(s)

Teodoro, Kelcilene B. R. ^[1] ; Sanfelice, Rafaela C. ^[2] ; Migliorini, Fernanda L. ^[1] ; Pavinatto, Adriana ^[3] ; Facure, Murilo H. M. ^{[4, 1]} ; Correa, Daniel S. ^{[4, 1]}

Affiliation

^[1] Embrapa Instrumentacao, Nanotechnol Natl Lab Agr, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Alfenas, Sci & Technol Inst, BR-37715400 Pocos De Caldas, MG - Brazil

^[3] Brazil Univ, Sci & Technol Inst, BR-08230030 Sao Paulo - Brazil

^[4] Fed Univ Sao Carlos UFSCar, Ctr Exact Sci & Technol, Dept Chem, PPGQ, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Review article
• Source: ACS SENSORS; v. 6, n. 7, p. 2473-2496, JUL 23 2021.
• Web of Science Citations: 1

Abstract

Sensors and biosensors play a key role as an analytical tool for the rapid, reliable, and early diagnosis of human diseases. Such devices can also be employed for monitoring environmental pollutants in air and water in an expedited way. More recently, nanomaterials have been proposed as an alternative in sensor fabrication to achieve gains in performance in terms of sensitivity, selectivity, and portability. In this direction, the use of cellulose nanomaterials (CNM), such as cellulose nanofibrils (CNF), cellulose nanocrystals (CNC), and bacterial cellulose (BC), has experienced rapid growth in the fabrication of varied types of sensors. The advantageous properties are related to the supramolecular structures that form the distinct CNM, their biocompatibility, and highly reactive functional groups that enable surface functionalization. The CNM can be applied as hydrogels and xerogels, thin films, nanopapers and other structures interesting for sensor design. Besides, CNM can be combined with other materials (e.g., nanoparticles, enzymes, carbon nanomaterials, etc.) and varied substrates to advanced sensors and biosensors fabrication. This review explores recent advances on CNM and composites applied in the fabrication of optical, electrical, electrochemical, and piezoelectric sensors for detecting analytes ranging from environmental pollutants to human physiological parameters. Emphasis is given to how cellulose nanomaterials can contribute to enhance the performance of varied sensors as well as expand novel sensing applications, which could not be easily achieved using standard materials. Finally, challenges and future trends on the use of cellulose-based materials in sensors and biosensors are also discussed. (AU)

• FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
• Grantee: Osvaldo Novais de Oliveira Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/21791-7 - Development of electrochemical and colorimetric biosensors for detecting micotoxins
• Grantee: Fernanda Lanzoni Migliorini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/19470-8 - Development of portable biosensor for non-invasive detection of uric acid as indicative of hyperuricemia
• Grantee: Adriana Pavinatto da Costa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/12174-4 - Development of hybrid polymer nanofibers for agricultural applications
• Grantee: Daniel Souza Corrêa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/10582-8 - Production and characterization of graphene quantum dots and their application in chemical sensors
• Grantee: Murilo Henrique Moreira Facure
• Support Opportunities: Scholarships in Brazil - Doctorate