Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of natural latex membranes on wound repair of palate donor areas: A pilot randomized controlled trial study, including the membranes characterization

Full text
Author(s):
Spin, Jose Rodolfo [1] ; de Oliveira, Guilherme Jose Pimentel Lopes [2] ; Spin-Neto, Rubens [3] ; Herculano, Rondinelli Donizetti [4] ; Marcantonio, Rosemary Adriana Chierici [1]
Total Authors: 5
Affiliation:
[1] Sa Paulo State Univ Unesp, Sch Dent, Dept Diag & Surg, Araraquara, SP - Brazil
[2] Fed Univ Uberlandia UFU, Sch Dent, Uberlandia, MG - Brazil
[3] Aarhus Univ, Dept Dent & Oral Hlth, Aarhus - Denmark
[4] Sa Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Bioproc & Biotechnol, Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: MATERIALS TODAY COMMUNICATIONS; v. 27, JUN 2021.
Web of Science Citations: 0
Abstract

The aim of the present study was to evaluate the use of an exclusively developed latex membrane, to act as physical barrier to aid wound healing, epithelization, and pain in the palate region after free gingival graft harvesting. Latex membranes were physically, chemically, and mechanically characterized before application. Twenty-four patients (age 30-70 years, mean 45 years), requiring free gingival graft were sequentially selected, and randomly divided in two groups according to type of protection utilized on the donor site, control group (14 patients)- The wound in palate was covered with acrylic plate and surgical cement only and test group (10 patients) - The wound in palate was covered with the experimental latex membrane. The palate region was evaluated on the surgery day and 3, 7, 15, and 30 days after the surgical procedure for wound healing area, epithelization, bleeding, and self-reported pain (VAS). Wound reduction between periods was calculated, as percentage. The membrane had smooth surface, high elasticity, and nanoscale porosity, as expected for biomedical application. At 15 days, control group patients presented a fully healed wound, while mean wound closure was 98.6 % in the latex group. At 30 days, both groups presented complete wound closure. Also, at 30 days, there was no significant epithelization difference between the groups, and all patients in both presented fully epithelized wounds. As for bleeding, at 7 days it was positive for 21.4 % of the patients in the control group, while it was already negative for all patients in the latex group. Regarding reported pain, VAS values were larger in the control group, although with no statistical significance. Latex membranes did not delay the healing of the palate or caused visible adverse effects (i.e. allergies, discomfort, or injury to the patient), when compared to the control group. (AU)

FAPESP's process: 17/19603-8 - Development of a novel patch containing latex and barbatimam e fractions and study of signaling pathways in cutaneous wound repair
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 16/00275-8 - Antimicrobial photodynamic therapy (aPDT) in the treatment of periodontal disease induced in rats
Grantee:Rosemary Adriana Chierici Marcantonio
Support Opportunities: Regular Research Grants