Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biocompatible Photoinduced Alkylation of Dehydroalanine for the Synthesis of Unnatural alpha-Amino Acids

Full text
Author(s):
Delgado, Jose A. C. [1] ; Correia, Jose T. M. [1] ; Pissinati, Emanuele F. [1] ; Paixao, Marcio W. [1]
Total Authors: 4
Affiliation:
[1] Fed Univ Sao Carlos UFSCar, Ctr Excellence Res Sustainable Chem CERSusChem, Dept Chem, BR-13565905 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ORGANIC LETTERS; v. 23, n. 13, p. 5251-5255, JUL 2 2021.
Web of Science Citations: 0
Abstract

A site-selective alkylation of dehydroalanine to access protected unnatural amino acids is described. The protocol is characterized by the wide nature of alkyl radicals employed, mild conditions, and functional group compatibility. This protocol is further extended to access peptides, late-stage functionalization of pharmaceuticals, and enantioenriched amino acids. (AU)

FAPESP's process: 19/01973-9 - Exploration of the Asymmetric Induction in Ugi Variations Aiming the Stereoselective Synthesis and Functionalizationof N-Heterocycles
Grantee:Vitor Alcantara Fernandes da Silva
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support Opportunities: Research Grants - Research Centers in Engineering Program
FAPESP's process: 17/10015-6 - Photocatalysis Applied to the Synthesis of N-heterocycles: New Strategies for Intercepting Radical Intermediates Generated in Processes Promoted by Visible-light-Tris (trimethylsilyl)silane Combination.
Grantee:José Tiago Menezes Correia
Support Opportunities: Scholarships in Brazil - Post-Doctoral