Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies

Author(s)

Soares, Diana G. ^[1] ; Bordini, Ester A. F. ^{[2, 3]} ; Swanson, W. Benton ^[4] ; de Souza Costa, Carlos A. ^[3] ; Bottino, Marco C. ^{[2, 5]}

Affiliation

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Operat Dent Endodont & Dent Mat, BR-17012901 Bauru, SP - Brazil

^[2] Univ Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 - USA

^[3] Univ Estadual Paulista UNESP, Araraquara Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP - Brazil

^[4] Univ Michigan, Sch Dent, Dept Biol & Mat Sci, Div Prosthodont, Ann Arbor, MI 48109 - USA

^[5] Univ Michigan, Sch Dent, Dept Biomed Engn, Coll Engn, Ann Arbor, MI 48109 - USA

• Document type: Review article
• Source: CLINICAL ORAL INVESTIGATIONS; v. 25, n. 8, p. 4749-4779, AUG 2021.
• Web of Science Citations: 0

Abstract

Objectives The aim of this review is to highlight recent progress in the field of biomaterials-mediated dental pulp tissue engineering. Specifically, we aim to underscore the critical design criteria of biomaterial platforms that are advantageous for pulp tissue engineering, discuss models for preclinical evaluation, and present new and innovative multifunctional strategies that hold promise for clinical translation. Materials and methods The current article is a comprehensive overview of recent progress over the last 5 years. In detail, we surveyed the literature in regenerative pulp biology, including novel biologic and biomaterials approaches, and those that combined multiple strategies, towards more clinically relevant models. PubMed searches were performed using the keywords: ``regenerative dentistry,{''} ``dental pulp regeneration,{''} ``regenerative endodontics,{''} and ``dental pulp therapy.{''} Results Significant contributions to the field of regenerative dentistry have been made in the last 5 years, as evidenced by a significant body of publications. We chose exemplary studies that we believe are progressive towards clinically translatable solutions. We close this review with an outlook towards the future of pulp regeneration strategies and their clinical translation. Conclusions Current clinical treatments lack functional and predictable pulp regeneration and are more focused on the treatment of the consequences of pulp exposure, rather than the restoration of healthy dental pulp. (AU)

• FAPESP's process: 16/15674-5 - Association of tissue engineering techniques for mineralized tissue regeneration under degenerative inflammatory stimulus: analysis on 3D-culture perfusion bioreactor and animal inflammatory models
• Grantee: Diana Gabriela Soares dos Passos
• Support Opportunities: Research Grants - Young Investigators Grants