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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

olecular organization in hydroperoxidized POPC bilayer

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Author(s):
Junqueira, Helena [1, 2] ; Schroder, Andre P. [3, 4] ; Thalmann, Fabrice [3] ; Klymchenko, Andrey [5] ; Mely, Yves [5] ; Baptista, Mauricio S. [1] ; Marques, Carlos M. [3]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Fis, Dept Fis Aplicada, CP 66318, BR-05314970 Sao Paulo - Brazil
[3] Univ Strasbourg, CNRS, Inst Charles Sadron UPR22, F-67000 Strasbourg - France
[4] Univ Lyon, INSA Lyon, CNRS UMR5259, LaMCoS, F-69621 Villeurbanne - France
[5] Univ Strasbourg, Lab Bioimagerie & Pathol, UMR 7021 CNRS, Fac Pharm, 74 Route Rhin, CS 60024, F-67401 Illkirch Graffenstaden - France
Total Affiliations: 5
Document type: Journal article
Source: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES; v. 1863, n. 10 OCT 2021.
Web of Science Citations: 0
Abstract

Lipid hydroperoxides are the primary reaction products of lipid oxidation, a natural outcome of life under oxygen. While playing a major role in cell metabolism, the microscopic origins of the effects of lipid hydroperoxidation on biomembranes remain elusive. Here we probe the polar structure of partially to fully hydroperoxidized bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) by a combination of environment-sensitive fluorescent probes and coarse-grained Martini numerical simulations. We find that the inserted organic hydroperoxide group -OOH migrates preferentially to the surface for bilayers with small fractions of hydroperoxidized lipids, but populates also significantly the bilayer interior for larger fractions. Our findings suggest that by modifying the intimate polarity of biomembranes, lipid peroxidation will have a significant impact on the activity of transmembrane proteins and on the bio-medical efficiency of membrane active molecules such as cell-penetrating and antimicrobial peptides. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/11640-0 - Relationship between the photoinduced damage in lipids and membrane permeabilization
Grantee:Isabel de Oliveira Lima Bacellar
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)