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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lateral hypothalamus involvement in control of stress response by bed nucleus of the stria terminalis endocannabinoid neurotransmission in male rats

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Author(s):
Gomes-de-Souza, Lucas [1, 2] ; Costa-Ferreira, Willian [1, 2] ; Mendonca, Michelle M. [3] ; Xavier, Carlos H. [3] ; Crestani, Carlos C. [1, 2, 4]
Total Authors: 5
Affiliation:
[1] Joint UFSCar UNESP Grad Program Physiol Sci, Sao Carlos, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Lab Pharmacol, Araraquara, SP - Brazil
[3] Univ Fed Goias, Inst Biol Sci, Goiania, Go - Brazil
[4] S5o Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Dept Drugs & Pharmaceut, Lab Pharmacol, Rodovia Araraquara Jau Km 01, Campus Univ, BR-14800903 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 11, n. 1 AUG 9 2021.
Web of Science Citations: 0
Abstract

The endocannabinoid neurotransmission acting via local CB1 receptor in the bed nucleus of the stria terminalis (BNST) has been implicated in behavioral and physiological responses to emotional stress. However, the neural network related to this control is poorly understood. In this sense, the lateral hypothalamus (LH) is involved in stress responses, and BNST GABAergic neurons densely innervate this hypothalamic nucleus. However, a role of BNST projections to the LH in physiological responses to stress is unknown. Therefore, using male rats, we investigated the role of LH GABAergic neurotransmission in the regulation of cardiovascular responses to stress by CB1 receptors within the BNST. We observed that microinjection of the selective CB1 receptor antagonist AM251 into the BNST decreased the number of Fos-immunoreactive cells within the LH of rats submitted to acute restraint stress. Treatment of the BNST with AM251 also enhanced restraint-evoked tachycardia. Nevertheless, arterial pressure increase and sympathetically-mediated cutaneous vasoconstriction to restraint was not affected by CB1 receptor antagonism within the BNST. The effect of AM251 in the BNST on restraint-evoked tachycardia was abolished in animals pretreated with the selective GABA(A) receptor antagonist SR95531 in the LH. These results indicate that regulation of cardiovascular responses to stress by CB1 receptors in the BNST is mediated by GABAergic neurotransmission in the LH. Present data also provide evidence of the BNST endocannabinoid neurotransmission as a mechanism involved in LH neuronal activation during stressful events. (AU)

FAPESP's process: 16/05028-9 - Control of cardiovascular responses to stress by endocannabinoid neurotransmission in the bed nucleus of the stria terminalis in rats: interaction with the NMDA receptor/NO/cGMP/protein kinase g signaling pathway and involvement of lateral hypothalamus
Grantee:Lucas Gomes de Souza
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/05218-2 - Involvement of the Angiotensin II / AT1 receptor angiotensin 1-7 / Mas receptor signaling in the medial nucleus of the amygdala in the cardiovascular and anxiogenic responses to stress in rats
Grantee:Willian Costa Ferreira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/24478-3 - Role of the insular cortex in control of the cardiovascular and anxiogenic responses to stress in rats: evaluation of functional topography and involvement of corticotropin-releasing factor (CRF) neurotransmission
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants
FAPESP's process: 17/19249-0 - Involvement of angiotensinergic neurotransmissions of medial amygdaloid nucleus in control of cardiovascular and anxiogenic responses to stress in rats.
Grantee:Carlos Cesar Crestani
Support Opportunities: Regular Research Grants