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Study of the involvement of endocannabinoid system into the prefrontal medial cortex on food intake of rats

Grant number: 13/13721-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2013
Effective date (End): October 31, 2017
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Fernando Morgan de Aguiar Correa
Grantee:América Scopinho Augusto
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:12/17626-7 - Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders, AP.TEM

Abstract

The control of metabolism and eating behavior is highly complex and is regulated by neurotransmitters and neuromodulators present in the central nervous system (CNS).The hypothalamus is the main structure involved in the regulation of food intake, however, this structure is modulated by other areas of the CNS, especially, limbic strutures that are involved in the control of emotions and behavioral responses, such as the paraventricular nucleus of hypothalamus, septal area, nucleus accumbens, bed nucleus of stria terminalis, the amygdala,córtex among others. In particular, the medial prefrontal cortex (MPFC), which is subdivided into 1 and 2 cingulate cortex (CG1 and CG2), prelimbic (Cg3, PL), infralímbic (IL) and dorsopeduncular (DP), have been shown part of the motivation to eat and in addition, this area have connections to the hypothalamus. Although there is evidence in the literature that demonstrate the involvement of MPFC in the modulation of food intake, it is not known what the possible neurotransmitters involved in this modulation. Among the neurotransmission present in the MPFC, the role played by the endocannabinoid system is little known.Endocannabinoids are involved in the regulation of appetite and induce an increase in food intake in animal and human models. Moreover, the CB1 receptor blockade reduces food intake. The endocannabinoid signaling system has proved promising in the context of research on eating disorders such as anorexia nervosa and obesity. These diseases are of great concern today and has received special attention in recent decades due to the large number of affected individuals. But while these studies are of great importance, it is not known completely the role of the endocannabinoid system in the central nervous system and neither about which brain structures would be acting. Therefore, the aim of the present study is to investigate the role of the endocannabinoid system in the PL and IL cortices on modulation of feeding behavior in the rat.

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES-AZEVEDO, SILVANA; TRINDADE FORTALEZA, EDUARDO ALBINO; BUSNARDO, CRISTIANE; SCOPINHO, AMERICA AUGUSTO; MATTHIESEN, MELINA; ANTUNES-RODRIGUES, JOSE; AGUIAR CORREA, FERNANDO MORGAN. The Supraoptic Nucleus of the Hypothalamus Modulates Autonomic, Neuroendocrine, and Behavioral Responses to Acute Restraint Stress in Rats. Neuroendocrinology, v. 110, n. 1-2, p. 10-22, JAN 2020. Web of Science Citations: 0.
HARTMANN, ALICE; FASSINI, ALINE; SCOPINHO, AMERICA; CORREA, FERNANDO M. A.; GUIMARAES, FRANCISCO S.; LISBOA, SABRINA F.; RESSTEL, LEONARDO B. M. Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 5, p. 606-614, MAY 2019. Web of Science Citations: 0.
FASSINI, ALINE; SCOPINHO, AMERICA A.; ALVES, FERNANDO H. F.; FORTALEZA, EDUARDO A. T.; CORREA, FERNANDO M. A. THE MEDIAL PREOPTIC AREA MODULATES AUTONOMIC FUNCTION UNDER RESTING AND STRESS CONDITIONS. Neuroscience, v. 364, p. 164-174, NOV 19 2017. Web of Science Citations: 1.
FASSINI, ALINE; SCOPINHO, AMERICA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A. NOP receptors in the prelimbic cortex have an inhibitory influence on cardiovascular responses induced by restraint stress. Neuropeptides, v. 57, p. 35-44, JUN 2016. Web of Science Citations: 2.

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