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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic training associated with an active lifestyle exerts a protective effect against oxidative damage in hypothalamus and liver: The involvement of energy metabolism

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Author(s):
Scariot, Pedro P. M. [1] ; Manchado-Gobatto, Fulvia B. [1] ; Van Ginkel, Paul R. [2] ; Prolla, Tomas A. [2] ; Gobatto, Claudio A. [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Sch Appl Sci, Lab Appl Sport Physiol, Pedro Zaccaria St 1-300, BR-13484350 Limeira, SP - Brazil
[2] Univ Wisconsin, Dept Genet & Med Genet, Madison, WI - USA
Total Affiliations: 2
Document type: Journal article
Source: Brain Research Bulletin; v. 175, p. 116-129, OCT 2021.
Web of Science Citations: 0
Abstract

Background: Oxidation resistance protein 1 (OXR1) is of scientific interest due its role in protecting tissues against oxidative stress, DNA mutations and tumorigenesis, but little is known regarding strategies to increase OXR1 in different tissues. As an improved antioxidant defense may result from a high total amount of physical activity, the present study was designed to determine whether an active lifestyle including aerobic training exercise and spontaneous physical activity (SPA) can increase OXR1. We have built a large cage (LC) that allows animals to move freely, promoting an increase in SPA in comparison to a small cage (SC). Methods: We examined the effects of aerobic training applied for 8 weeks on SPA and OXR1 of C57BL/6 J mice living in two types of housing (SC and LC). OXR1 protein was studied in hypothalamus, muscle and liver, which were chosen due to their important role in energy and metabolic homeostasis. Results: LC-mice were more active than SC-mice as determined by SPA values. Despite both trained groups exhibiting similar gains in aerobic capacity, only trained mice kept in a large cage (but not for trained mice housed in SC) exhibited high OXR1 in the hypothalamus and liver. Trained mice housed in LC that exhibited an up-regulation of OXR1 also were those who exhibited an energy-expensive metabolism (based on metabolic parameters). Conclusions: These results suggest that aerobic training associated with a more active lifestyle exerts a protective effect against oxidative damage and may be induced by changes in energy metabolism. (AU)

FAPESP's process: 17/10201-4 - Effects of aerobic physical training and the availability of wide space housing on the spontaneous physical activity, central and peripheral metabolic and molecular responses
Grantee:Claudio Alexandre Gobatto
Support Opportunities: Regular Research Grants
FAPESP's process: 19/05115-7 - Effects of aerobic training and the hypoxic environment on molecular responses related to anaerobic and aerobic metabolism and acid-base properties in the hypothalamus and skeletal muscle of mice
Grantee:Pedro Paulo Menezes Scariot
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/01362-9 - Effects of age, caloric restriction diet (Cr) and SIRT3 on spontaneous activity, behavior and oxidative mediators (NO, NOS and orexin) and hypothalamic mitochondrial respiration
Grantee:Claudio Alexandre Gobatto
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 15/00272-6 - Effects of caloric restriction mediated by SIRT3 in the aerobic and anaerobic capacities of mice: relations with the spontaneous activity, metabolic parameters and muscle mitochondrial function in aging process
Grantee:Fúlvia de Barros Manchado Gobatto
Support Opportunities: Scholarships abroad - Research