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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epstein-Barr virus oral shedding and viremia and their association with oral hairy leukoplakia in HIV plus individuals

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Author(s):
Feijo Rosseto, Jose Henrique [1] ; Tenorio, Jefferson Rocha [1, 2] ; Mamana, Ana Carolina [3] ; Tozetto-Mendoza, Tania Regina [3] ; Andrade, Natalia Silva [4] ; Braz-Silva, Paulo Henrique [1, 3] ; Ortega, Karem L. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo - Brazil
[2] Univ Fed Rio de Janeiro, Sch Dent, Dept Pathol & Oral Diag, R Prof Rodolpho Paulo Rocco 325, BR-21941617 Rio De Janeiro, RJ - Brazil
[3] Univ Sao Paulo, Sch Med, Inst Trop Med Sao Paulo, Lab Virol, Sao Paulo, SP - Brazil
[4] Univ Fed Sergipe, Sch Dent, Dept Dent, Lagarto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ORAL DISEASES; AUG 2021.
Web of Science Citations: 0
Abstract

Objective To assess the oral shedding and viremia of Epstein-Barr virus (EBV) in HIV-positive patients and their relationship with oral hairy leukoplakia (OHL). Methodology A total of 94 HIV-positive patients were included in the study, in which blood and saliva samples were collected for EBV quantification. Data on gender, age, time of HIV seropositivity, combined antiretroviral therapy (cART), CD4+ T-cell counts, and HIV viral load were collected. OHL diagnosis was based on histopathological examination and EBV in situ hybridization. Results The EBV load in the 94 HIV-positive patients was higher in saliva than in blood (2.4 and 1.6, respectively), and there was a positive correlation between EBV oral shedding and viremia (p = 0.001). Twenty (21.27%) patients had OHL and also a higher EBV load in saliva (mean log(10) = 3.11) compared to those who had no OHL (p = 0.045). Presence of OHL was only associated with age (p = 0.030). Conclusion In HIV-positive patients, the presence of OHL was associated with EBV oral shedding but not with viremia, regardless of the amount of circulating CD4+ T cells. (AU)

FAPESP's process: 15/07727-9 - Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not.
Grantee:Paulo Henrique Braz da Silva
Support Opportunities: Regular Research Grants