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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Potential Use of DMSA-Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID-19 Disease

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Author(s):
Martins, Elisama S. [1] ; Espindola, Ariane [1, 2] ; Britos, Tatiane N. [1] ; Chagas, Camila [3] ; Barbosa, Emerson [3] ; Castro, Carlos E. [4] ; Fonseca, Fernando L. A. [1, 3] ; Haddad, Paula S. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Chem, Rua Sao Nicolau 210, BR-09961400 Diadema, SP - Brazil
[2] Univ Haute Alsace, Inst Sci Mat Mulhouse IS2 M, 15 Rue Jean Starcky, F-68057 Mulhouse - France
[3] Fac Med ABC FMABC, Ave Principe Gales 667, BR-09060590 Santo Andre, SP - Brazil
[4] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CHEMISTRYSELECT; v. 6, n. 31, p. 7931-7935, AUG 20 2021.
Web of Science Citations: 0
Abstract

Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID-19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with meso-2,3-dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid-state and are superparamagnetic at room temperature. There is no toxicity of SPIONS-DMSA under the cells of patients with COVID-19. Taken together the results show that DMSA- Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells. (AU)

FAPESP's process: 18/12219-0 - Evaluation of toxicity and antineoplastic action in BALB/c mice inoculated with Ehrlich's Tumor treated with superparamagnetic nanoparticles
Grantee:Camila dos Santos Chagas
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/15061-6 - Preparation, Characterization and Biological Essay of Nanostructured Materials Based on Superparamagnetic Metallic and Bimetallic Nanoparticles
Grantee:Paula Silvia Haddad Ferreira
Support type: Regular Research Grants
FAPESP's process: 19/07454-3 - Preparation and structural and magnetic investigation of metal and bimetallic Fe nanoparticles as potential drug carrier vehicles
Grantee:Elisama Silva Martins
Support type: Scholarships in Brazil - Scientific Initiation