Martins, Elisama S.
Britos, Tatiane N.
Castro, Carlos E.
Fonseca, Fernando L. A.
Haddad, Paula S.
Total Authors: 8
 Univ Fed Sao Paulo, Dept Chem, Rua Sao Nicolau 210, BR-09961400 Diadema, SP - Brazil
 Univ Haute Alsace, Inst Sci Mat Mulhouse IS2 M, 15 Rue Jean Starcky, F-68057 Mulhouse - France
 Fac Med ABC FMABC, Ave Principe Gales 667, BR-09060590 Santo Andre, SP - Brazil
 Fed Univ ABC UFABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 4
AUG 20 2021.
Web of Science Citations:
Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID-19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with meso-2,3-dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid-state and are superparamagnetic at room temperature. There is no toxicity of SPIONS-DMSA under the cells of patients with COVID-19. Taken together the results show that DMSA- Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells. (AU)