From circular synthesis to material manufacturing: advances, challenges, and future steps for using flow chemistry in novel application area

Author(s)

Sivo, Alessandra ^[1] ; Galaverna, Renan de Souza ^[2] ; Gomes, Gustavo Rodrigues ^[2] ; Pastre, Julio Cezar ^[2] ; Vile, Gianvito ^[1]

Affiliation

^[1] Politecn Milan, Dept Chem Mat & Chem Engn Giulio Natta, Piazza Leonardo da Vinci 32, IT-20131 Milan - Italy

^[2] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil

• Document type: Review article
• Source: REACTION CHEMISTRY & ENGINEERING; v. 6, n. 5, p. 756-786, MAY 1 2021.
• Web of Science Citations: 4

Abstract

Continuous-flow technologies are becoming increasingly relevant in the chemistry field. The vast arrays of reactor design, in terms of structural geometry, mixing, and residence time, the modularity of these systems, adaptable for every application, and the easy downstream integrations are at the basis for their success. Over the past decade, the value and potential of flow technologies became apparent, particularly for drug discovery and drug development. However, other areas of research, which include the circular valorization of waste products and the manufacturing of materials and catalysts, have been less touched by the revolution that miniaturization brings in terms of efficiency, safety, environmental impact, and processability. This review critically evaluates the emerging use of flow technologies in these areas, highlighting recent advances, current challenges, and future directions in the quest for leaner and cleaner processing methods. (AU)

• FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
• Grantee: Carlos Roque Duarte Correia
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/26378-2 - Development of methodologies and synthetic processes employing a new technological platform: micro and meso reactor assisted synthesis of natural products and derivatives with potential pharmacological activity
• Grantee: Júlio Cezar Pastre
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 18/09861-2 - Synthesis of novel ionic liquids from renewable sources and application on biomass conversion
• Grantee: Gustavo Rodrigues Gomes
• Support Opportunities: Scholarships in Brazil - Doctorate