| Full text | |
| Author(s): Show less - |
Gualandro, Danielle M.
[1, 2, 3]
;
Puelacher, Christian
[1, 2]
;
Lurati Buse, Giovanna
[4]
;
Glarner, Noemi
[1, 2]
;
Cardozo, Francisco A.
[3]
;
Vogt, Ronja
[1, 2]
;
Hidvegi, Reka
[1, 2]
;
Strunz, Celia
[5]
;
Bolliger, Daniel
[6]
;
Gueckel, Johanna
[1, 2]
;
Yu, Pai C.
[3]
;
Liffert, Marcel
[1, 2, 6]
;
Arslani, Ketina
[1, 2]
;
Prepoudis, Alexandra
[1, 2]
;
Calderaro, Daniela
[3]
;
Hammerer-Lercher, Angelika
[7]
;
Lampart, Andreas
[6]
;
Steiner, Luzius A.
[8, 9]
;
Schaeren, Stefan
[10]
;
Kindler, Christoph
[11]
;
Guerke, Lorenz
[12]
;
Osswald, Stefan
[1, 2]
;
Devereaux, P. J.
[13]
;
Caramelli, Bruno
[3]
;
Mueller, Christian
[1, 2]
;
Marbot, Stella
;
Strebel, Ivo
;
Genini, Alessandro
;
Rentsch, Katharina
;
Boeddinghaus, Jasper
;
Nestelberger, Thomas
;
Wild, Karin
;
Zimmermann, Tobias
;
Duarte, Alberto J. S.
;
Buser, Andreas
;
de Luccia, Nelson
;
Koechlin, Luca
;
Wussler, Desiree
;
Walter, Joan
;
Widmer, Velina
;
Freese, Michael
;
Lopez-Ayala, Pedro
;
Twerenbold, Raphael
;
Badertscher, Patrick
;
Seeberger, Esther
;
Wolff, Thomas
;
Mujagic, Edin
;
Mehrkens, Arne
;
Dinort, Julia
;
Fahrni, Gregor
;
Jeger, Raban
;
Kaiser, Christoph
;
Matheus, Mariana
;
Pastana, Adriana F.
;
Investigators, BASEL PMI
Total Authors: 55
|
| Affiliation: Show less - | [1] Univ Basel, Univ Hosp Basel, Dept Cardiol, Spitalstr 2, CH-4056 Basel - Switzerland
[2] Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel CRIB, Spitalstr 2, CH-4056 Basel - Switzerland
[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, Interdisciplinary Med Cardiol Unit, Cardiol Dept, Sao Paulo - Brazil
[4] Univ Hosp Dusseldorf, Dept Anesthesiol, Dusseldorf - Germany
[5] Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Med, Sao Paulo - Brazil
[6] Univ Basel, Univ Hosp Basel, Dept Anesthesiol, Basel - Switzerland
[7] Cantonal Hosp Aarau, Dept Lab Med, Aarau - Switzerland
[8] Univ Basel, Dept Lab Med, Basel - Switzerland
[9] Univ Basel, Dept Clin Res, Basel - Switzerland
[10] Univ Hosp Basel, Dept Spinal Surg, Basel - Switzerland
[11] Cantonal Hosp Aarau, Dept Anesthesiol, Aarau - Switzerland
[12] Univ Basel, Univ Hosp Basel, Dept Vasc Surg, Basel - Switzerland
[13] McMaster Univ, Populat Hlth Res Inst, David Braley Cardiac Vasc & Stroke Res Inst, Hamilton Gen Hosp, Anesthesiol Perioperat Med & Su, Hamilton, ON - Canada
Total Affiliations: 13
|
| Document type: | Journal article |
| Source: | Clinical Research in Cardiology; v. 110, n. 9, SI, p. 1450-1463, SEP 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Perioperative myocardial infarction/injury (PMI) diagnosed by high-sensitivity troponin (hs-cTn) T is frequent and a prognostically important complication of non-cardiac surgery. We aimed to evaluate the incidence and outcome of PMI diagnosed using hs-cTnI, and compare it to PMI diagnosed using hs-cTnT. Methods We prospectively included 2455 patients at high cardiovascular risk undergoing 3111 non-cardiac surgeries, for whom hs-cTnI and hs-cTnT concentrations were measured before surgery and on postoperative days 1 and 2. PMI was defined as a composite of perioperative myocardial infarction (PMIInfarct) and perioperative myocardial injury (PMIInjury), according to the Fourth Universal Definition of Myocardial Infarction. All-cause mortality was the primary endpoint. Results Using hs-cTnI, the incidence of overall PMI was 9% (95% confidence interval {[}CI] 8-10%), including PMIInfarct 2.6% (95% CI 2.0-3.2) and PMIInjury 6.1% (95% CI 5.3-6.9%), which was lower versus using hs-cTnT: overall PMI 15% (95% CI 14-16%), PMIInfarct 3.7% (95% CI 3.0-4.4) and PMIInjury 11.3% (95% CI 10.2-12.4%). All-cause mortality occurred in 52 (2%) patients within 30 days and 217 (9%) within 1 year. Using hs-cTnI, both PMIInfarct and PMIInjury were independent predictors of 30-day all-cause mortality (adjusted hazard ratio {[}aHR] 2.5 {[}95% CI 1.1-6.0], and aHR 2.8 {[}95% CI 1.4-5.5], respectively) and, 1-year all-cause mortality (aHR 2.0 {[}95% CI 1.2-3.3], and aHR 1.8 {[}95% CI 1.2-2.7], respectively). Overall, the prognostic impact of PMI diagnosed by hs-cTnI was comparable to the prognostic impact of PMI using hs-cTnT. Conclusions Using hs-cTnI, PMI is less common versus using hs-cTnT. Using hs-cTnI, both PMIInfarct and PMIInjury remain independent predictors of 30-day and 1-year mortality. {[}GRAPHICS] . (AU) | |
| FAPESP's process: | 15/23731-6 - Evaluation of high- sensitive troponin elevation and cardiovascular events after vascular surgery |
| Grantee: | Danielle Menosi Gualandro |
| Support Opportunities: | Regular Research Grants |