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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Treatment strategies for glucose-6-phosphate dehydrogenase deficiency: past and future perspectives

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Author(s):
Garcia, Adriana A. [1] ; Koperniku, Ana [1] ; Ferreira, Julio C. B. [2, 1] ; Mochly-Rosen, Daria [1]
Total Authors: 4
Affiliation:
[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 - USA
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: TRENDS IN PHARMACOLOGICAL SCIENCES; v. 42, n. 10, p. 829-844, OCT 2021.
Web of Science Citations: 0
Abstract

Glucose-6-phosphate dehydrogenase (G6PD) maintains redox balance in a variety of cell types and is essential for erythrocyte resistance to oxidative stress. G6PD deficiency, caused by mutations in the G6PD gene, is present in similar to 400 million people worldwide, and can cause acute hemolytic anemia. Currently, there are no therapeutics for G6PD deficiency. We discuss the role of G6PD in hemolytic and nonhemolytic disorders, treatment strategies attempted over the years, and potential reasons for their failure. We also discuss potential pharmacological pathways, including glutathione (GSH) metabolism, compensatory NADPH production routes, transcriptional upregulation of the G6PD gene, highlighting potential drug targets. The needs and opportunities described here may motivate the development of a therapeutic for hematological and other chronic diseases associated with G6PD deficiency. (AU)

FAPESP's process: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment
Grantee:Carlos Eduardo Negrão
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/18627-3 - Mechanisms of exercise-induced mitophagy: a new avenue to drug discovery
Grantee:Julio Cesar Batista Ferreira
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 19/25049-9 - Mitochondrial formyl peptides as signaling molecules in cardiac Ischemia-reperfusion injury
Grantee:Julio Cesar Batista Ferreira
Support Opportunities: Regular Research Grants