| Full text | |
| Author(s): |
Fioramonte, Mariana
[1]
;
Reis-de-Oliveira, Guilherme
[1]
;
Brandao-Teles, Caroline
[1]
;
Martins-de-Souza, Daniel
[1, 2, 3, 4]
Total Authors: 4
|
| Affiliation: | [1] Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, Campinas - Brazil
[2] Conselho Nacl Desenvolvimento Cient & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBION, Sao Paulo - Brazil
[3] DOr Inst Res & Educ IDOR, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Expt Med Res Cluster EMRC, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS; v. 1869, n. 12 DEC 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
hnRNP represent a large family of RNA-binding proteins related to regulation of transcriptional and translational processes. More specifically, hnRNPs play pivotal roles in the myelination of the central nervous system. The regulation of these proteins are associated with neurodegenerative and psychiatric disorders, including schizophrenia. hnRNPs were shown differentially regulated on schizophrenia postmortem brain tissue as well as in cultured oligodendrocytes treated with clozapine, a common antipsychotic used in schizophrenia treatment. Here we employed co-immunoprecipitation of hnRNP C1/C2 to investigate for the first time in a large-scale manner its interaction partners on cultured oligodendrocytes (MO3.13). Even preliminarily, results bring a more comprehensive description of hnRNP C1/C2 interaction network, and therefore insights regarding the potential role of this protein in the central nervous system in health and disease, warranting further investigation. (AU) | |
| FAPESP's process: | 18/01410-1 - Evaluating the effects of clozapine on immune system cells |
| Grantee: | Guilherme Reis-De-Oliveira |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/18715-4 - Establishment of the hnRNPs role on schizophrenia through protein interaction network mapping |
| Grantee: | Mariana Fioramonte |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/25588-1 - From the basic understanding to clinical biomarkers to schizophrenia: a neuroproteomics-centered multidisciplinary study |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/00098-7 - Multi-User Equipment approved in grant 2017/25588-1: cromatógrafo Acquity UPLC I-Class |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 17/25055-3 - The role of hnRNPs in oligodendrocytes and their implications on schizophrenia |
| Grantee: | Caroline Brandão Teles Rodrigues |
| Support Opportunities: | Scholarships in Brazil - Doctorate |