Mini-review: The suspected non-Alzheimer's disease pathophysiology

Author(s)

Rizzi, Liara ^[1] ; Balthazar, Marcio L. F. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Neurol, UNICAMP, Campinas, SP - Brazil

• Document type: Review article
• Source: Neuroscience Letters; v. 764, NOV 1 2021.
• Web of Science Citations: 0

Abstract

Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker-based concept that underlying etiology has not been completely understood. Refers to a group of individuals that are negative for amyloid biomarkers and positive for p-Tau and/or neurodegeneration. SNAP causes great research interest because it is not clear if they have a different biological basis from Alzheimer's disease (AD), or are in an early stage of AD itself. The pathological processes behind SNAP need to be clarified. This mini-review aims to summarize the main characteristics of SNAP, besides reporting challenges and promising biomarkers related to the concept. (AU)

• FAPESP's process: 18/15571-7 - Mapping the progression of subjective cognitive decline to mild cognitive impairment and Alzheimer´s disease dementia with multimodal biomarkers
• Grantee: Marcio Luiz Figueredo Balthazar
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 19/23028-4 - Characterization of individuals with suspected non-Alzheimer pathophysiology (SNAP) through multimodal biomarkers
• Grantee: Liara Rizzi
• Support Opportunities: Scholarships in Brazil - Post-Doctoral