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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrophilic oxysterols: generation, measurement and protein modification

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Author(s):
Miyamoto, Sayuri [1] ; Lima, Rodrigo S. [1] ; Inague, Alex [1] ; Viviani, Lucas G. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Dept Bioquim, Inst Quim, CP 26077, BR-05513970 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Free Radical Research; v. 55, n. 4, SI, p. 416-440, APR 3 2021.
Web of Science Citations: 2
Abstract

Cholesterol is an essential component of mammalian plasma membranes. Alterations in sterol metabolism or oxidation have been linked to various pathological conditions, including cardiovascular diseases, cancer, and neurodegenerative disorders. Unsaturated sterols are vulnerable to oxidation induced by singlet oxygen and other reactive oxygen species. This process yields reactive sterol oxidation products, including hydroperoxides, epoxides as well as aldehydes. These oxysterols, in particular those with high electrophilicity, can modify nucleophilic sites in biomolecules and affect many cellular functions. Here, we review the generation and measurement of reactive sterol oxidation products with emphasis on cholesterol hydroperoxides and aldehyde derivatives (electrophilic oxysterols) and their effects on protein modifications. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 17/13804-1 - Mechanisms of detoxification and repair of oxidized biological membranes involving the action of the enzyme peroxiredoxin 6
Grantee:Alex Inague
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)