A new natural detector for irradiations with blue LED light source in photodynamic therapy measurements via UV-Vis spectroscopy

Author(s)

de Oliveira, Lucas N. ^{[1, 2]} ; do Nascimento, Eriberto O. ^[2] ; Caldas, Linda V. E. ^[1]

Affiliation

^[1] Comissao Nacl Energia Nucl IPEN CNEN, Inst Pesquisas Energet & Nucl, Av Prof Lineu Prestes 2242, BR-05508000 Sao Paulo, SP - Brazil

^[2] Inst Fed Educ Ciencia & Tecnol Goias IFG, Rua 75, 46 Campus Goiania, BR-74055110 Goiania, Go - Brazil

• Document type: Journal article
• Source: PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES; v. 20, n. 11 SEP 2021.
• Web of Science Citations: 0

Abstract

Photodynamic therapy has been recently studied, bringing innovations regarding the reduction of exposure time to light by the patient. This work aimed to investigate the feasibility of using Coutarea hexandra (Jacq.) K. Schum (CHS) as a detector in photodynamic therapy measurements. For this, an irradiator containing a blue LED bulb lamp was utilized. The CHS samples were irradiated with ten doses from 0.60 up to 6.0 kJ/cm(2), and six concentrations were prepared (1, 2, 3, 4, 5, and 6 mg/ml) for the CHS detector samples. After irradiation, the detector samples were evaluated using UV-Vis spectrophotometry. The results showed the behavior of the CHS detector with doses and concentrations, its sensitivity, and its linearity was also evaluated both by Wavelength Method (WM) and the Kernel Principal Component Regression (KPCR) Statistical Method. The values obtained indicate that this method can be applied to the CHS sample detector. In conclusion, the CHS is a promising detector in the field of photodynamic therapy. (AU)

• FAPESP's process: 18/05982-0 - R&D&I in radiation metrology in the health area
• Grantee: Linda Viola Ehlin Caldas
• Support Opportunities: Research Projects - Thematic Grants