Bioactive Ag3PO4/Polypropylene Composites for Inactivation of SARS-CoV-2 and Other Important Public Health Pathogens

Author(s):Show less -

Ribeiro, Lara K. ^[1] ; Assis, Marcelo ^{[2, 1]} ; Lima, Lais R. ^[3] ; Coelho, Dyovani ^[1] ; Goncalves, Mariana O. ^[4] ; Paiva, Robert S. ^[3] ; Moraes, Leonardo N. ^{[5, 6]} ; Almeida, Lauana F. ^{[5, 6]} ; Lipsky, Felipe ^[7] ; San-Miguel, Miguel A. ^[7] ; Mascaro, Lucia H. ^[1] ; Grotto, Rejane M. T. ^{[5, 6]} ; Sousa, Cristina P. ^[4] ; Rosa, V, Ieda L. ; Cruz, Sandra A. ^[3] ; Andres, Juan ^[2] ; Longo, Elson ^[8]

Affiliation

^[1] Fed Univ Sao Carlos UFSCar, LIEC, CDMF, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Jaume I UJI, Dept Phys & Analyt Chem, Castellon de La Plana 12071 - Spain

^[3] Fed Univ Sao Carlos UFSCar, Chem Dept, BR-13565905 Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Carlos UFSCar, Biomol & Microbiol Lab LaMiB, Biotechnol Grad Program, BR-13565905 Sao Carlos, SP - Brazil

^[5] Sao Paulo State Univ UNESP, Sch Agr, BR-18610034 Botucatu, SP - Brazil

^[6] Sao Paulo State Univ Unesp, Clin Hosp Botucatu, Med Sch, Mol Lab, BR-18618687 Botucatu, SP - Brazil

^[7] State Univ Campinas UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil

^[8] Rosa, Ieda L., V, Fed Univ Sao Carlos UFSCar, LIEC, CDMF, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Journal of Physical Chemistry B; v. 125, n. 38, p. 10866-10875, SEP 30 2021.
• Web of Science Citations: 0

Abstract

The current unprecedented coronavirus pandemic (COVID-19) is increasingly demanding advanced materials and new technologies to protect us and inactivate SARS-CoV-2. In this research work, we report the manufacture of Ag3PO4(AP)/polypropylene (PP) composites using a simple method and also reveal their long-term anti-SARS-CoV-2 activity. This composite shows superior antibacterial (against Staphylococcus aureus and Escherichia coli) and antifungal activity (against Candida albicans), thus having potential for a variety of technological applications. The as-manufactured materials were characterized by XRD, Raman spectroscopy, FTIR spectroscopy, AFM, UV-vis spectroscopy, rheology, SEM, and contact angle to confirm their structural integrity. Based on the results of first-principles calculations at the density functional level, a plausible reaction mechanism for the initial events associated with the generation of both hydroxyl radical (OH)-O-center dot and superoxide radical anion O-center dot(2)- in the most reactive (110) surface of AP was proposed. AP/PP composites proved to be an attractive avenue to provide human beings with a broad spectrum of biocide activity. (AU)

• FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
• Grantee: Elson Longo da Silva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 16/23891-6 - Computer modeling of condensed matter
• Grantee: Alex Antonelli
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/11986-5 - Generation and storage of New Energy: bringing technological development for the country
• Grantee: Ana Flávia Nogueira
• Support Opportunities: Research Grants - Research Centers in Engineering Program
• FAPESP's process: 16/13423-5 - Compounds produced by endophyte microorganisms isolated from Brazilian tropical savannah: bioactivity, association with a-Ag2WO4 and biotechnological applications
• Grantee: Cristina Paiva de Sousa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/26105-4 - Multi-user equipment approved in grant 2016/23891-6 high performace computational cluster
• Grantee: Alex Antonelli
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 17/07711-0 - Detection of ZIKA Virus (ZIKV), after in vitro exposition, in the Peripheral Blood Mononuclear Cells and Platelets from non-infected individuals: Influence of the Genetic Polymorphisms
• Grantee: Rejane Maria Tommasini Grotto
• Support Opportunities: Regular Research Grants