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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic etiology of non-syndromic hearing loss in Latin America

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Author(s):
Lezirovitz, Karina [1] ; Mingroni-Netto, Regina Celia [2]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Hosp Clin, Fac Med, Lab Otorrinolaringol, LIM32, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Genet & Biol Evolut, Ctr Pesquisas Genoma Humano & Celulas Tronco, Inst Biociencias, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Human Genetics; OCT 2021.
Web of Science Citations: 0
Abstract

Latin America comprises all countries from South and Central America, in addition to Mexico. It is characterized by a complex mosaic of regions with heterogeneous genetic profiles regarding the geographical origin of the ancestors and proportions of admixture between the Native American, European and African components. In the first years following the findings of the role of the GJB2/GJB6 genes in the etiology of hearing loss, most scientific investigations about the genetics of hearing loss in Latin America focused on assessing the frequencies of pathogenic variants in these genes. More recently, modern techniques allowed researchers in Latin America to make exciting contributions to the finding of new candidate genes, novel mechanisms of inheritance in previously known genes, and characterize a wide diversity of variants, many of them unique to Latin America. This review aimed to provide a general landscape of the genetic studies about non-syndromic hearing loss in Latin America and their main scientific contributions. It allows the conclusion that, although there are similar contributions of some genes, such as GJB2/GJB6, when compared to European and North American countries, Latin American populations revealed some peculiarities that indicate the need for tailored strategies of screening and diagnosis to specific geographic regions. (AU)

FAPESP's process: 13/08028-1 - CEGH-CEL - Human Genome and Stem Cell Research Center
Grantee:Mayana Zatz
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC